PubMed-compiled information sheet
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Compiled from 2 PubMed articles · model: gemma4:31b
Summary
Hypericum kouytchense is a semi-evergreen plant of the Hypericaceae family used in traditional remedies and shown to contain protease inhibitors [PMID:36558950].
Background
Hypericum kouytchense Lével is a semi-evergreen shrub in the Hypericaceae family that is widely distributed and grows well in the karst regions of southwestern China [PMID:36558950, PMID:40805656].
Traditional uses
The roots and seeds of the plant have been utilized in traditional remedies for antimicrobial, antiviral, anti-inflammatory, detoxification, and antipyretic functions [PMID:36558950].
Active compounds
Ten compounds were identified and quantified in extracts from the insect gall of H. kouytchense using UPLC-HRMS [PMID:36558950].
Mechanism of action
Extracts from the insect gall of H. kouytchense act as inhibitors of HIV-1, cathepsin L, and human renin proteases [PMID:36558950].
Evidence summary
The current evidence is limited to in vitro protease inhibition studies and botanical nutrient analysis; there are no clinical trials or human studies available.
PubMed sources
- 1.PMID: 36558950 (2022) — Inhibitors of HIV-1 and Cathepsin L Proteases Identified from the Insect Gall of Hypericum kouytchense. · Pharmaceuticals (Basel, Switzerland)
- 2.PMID: 40805656 (2025) — Change in C, N, and P Characteristics of Hypericum kouytchense Organs in Response to Altitude Gradients in Karst Regions of SW China. · Plants (Basel, Switzerland)