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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Iceland Moss (Cetraria islandica) is a lichen used traditionally for respiratory and digestive conditions, demonstrating antioxidant, immunomodulating, and antiviral properties in experimental studies [PMID:35956939, 37298969].
Background
Cetraria islandica is a fruticose or subfoliose lichen primarily distributed in the Northern Hemisphere across North America and Eurasia [PMID:35956939]. It is a symbiotic organism composed of a fungus and a photosynthesizing partner, such as a green alga [PMID:23833245, 29535321].
Traditional uses
It has been widely employed in folk medicine for treating digestive and respiratory diseases, specifically as a demulcent for mouth and throat irritations, dry cough, and temporary loss of appetite [PMID:35956939, 36630529]. It is consumed as tea, food ingredients (e.g., soup or bread), and herbal medicines [PMID:29287470].
Active compounds
Identified compounds include depsidones (fumarprotocetraric and protocetraric acids), depsides, dibenzofuran derivatives (usnic acid), fatty acids (lichesterinic and protolichesterinic acids), and polysaccharides such as lichenan, isolichenan, and galactomannan [PMID:35956939, 36630529, 7646581].
Mechanism of action
Lichenan induces terminal cellular differentiation of primary human keratinocytes by upregulating gene clusters related to MAPK signaling [PMID:30031897]. Protolichesterinic acid demonstrates activity against Helicobacter pylori [PMID:8980785]. Polysaccharides exhibit immunostimulating activity by enhancing granulocytic phagocytosis [PMID:7809205, 23195981].
Clinical evidence
Evidence DInfluenza (A/H3N2 and A/H5N1)
Ethanol and aqueous extracts exhibited in vitro antiviral activity, with ethanol extracts being more potent at lower concentrations [PMID:37464197]
Evidence DOxidative Stress/Diabetes
Aqueous extracts showed ameliorative effects against diabetes-induced genetic and oxidative damage in human blood cells [PMID:23987663] and had no detrimental effects on liver histopathology in diabetic rats [PMID:24193057]
Evidence DGastric/Duodenal Ulcer (H. pylori)
Protolichesterinic acid showed in vitro susceptibility of Helicobacter pylori with MIC ranges of 16 to 64 micrograms/ml [PMID:8980785]
Evidence DGeneral Antioxidant Activity
Aqueous extracts demonstrated higher antioxidant activity and superoxide anion radical scavenging than alpha-tocopherol in linoleic acid emulsions [PMID:11849836]
Safety & adverse effects
Untreated or shortly boiled lichens were found to be lethally toxic to mice [PMID:3468923]. Lichens can concentrate heavy metals and airborne radionuclides (e.g., 210Po), which may pose health risks [PMID:28882460, 3468923]. Methanol extracts have been shown to increase micronucleus frequency in a dose-dependent manner in peripheral blood lymphocytes [PMID:24590925].
Dosage & administration
Traditionally used as decoctions, tinctures, aqueous extracts, and infusions [PMID:35956939]. Pretreatment methods such as ash-soaking have been used to reduce toxicity in animal models [PMID:3468923]. No PubMed data available. Consult a healthcare provider.
Evidence summary
The evidence is primarily based on in vitro studies, animal models, and phytochemical reviews (Level C and D). There are no human clinical trials (Level B) or meta-analyses (Level A) provided in the source material.
PubMed sources
1.PMID: 35956939 (2022) — The Genus Cetraria s. str.-A Review of Its Botany, Phytochemistry, Traditional Uses and Pharmacology. · Molecules (Basel, Switzerland)
2.PMID: 37464197 (2023) — Anti-Influenza Activity of Cetraria islandica Lichen Extracts in In Vitro Experiments. · Bulletin of experimental biology and medicine
3.PMID: 29287470 (2018) — Authentication of Iceland Moss (Cetraria islandica) by UPLC-QToF-MS chemical profiling and DNA barcoding. · Food chemistry
4.PMID: 37298969 (2023) — Ultrastructural, Energy-Dispersive X-ray Spectroscopy, Chemical Study and LC-DAD-QToF Chemical Characterization of Cetraria islandica (L.) Ach. · Molecules (Basel, Switzerland)
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Two-step isolation of the two major paraconic acids of Cetraria islandica.
· Journal of separation science
6.PMID: 18053625 (2008) — Susceptibility to acidic precipitation contributes to the decline of the terricolous lichens Cetraria aculeata and Cetraria islandica in central Europe. · Environmental pollution (Barking, Essex : 1987)
7.PMID: 7809205 (1994) — Immunologically active polysaccharide from Cetraria islandica. · Planta medica
8.PMID: 28482319 (2017) — Is there a risk of trace element contamination in herbal preparations? A test study on the lichen Cetraria islandica. · Chemosphere
9.PMID: 23987663 (2013) — The ameliorative effect of Cetraria islandica against diabetes-induced genetic and oxidative damage in human blood. · Pharmaceutical biology
10.PMID: 27064003 (2016) — Secondary metabolites from cetrarioid lichens: Chemotaxonomy, biological activities and pharmaceutical potential. · Phytomedicine : international journal of phytotherapy and phytopharmacology
11.PMID: 33391192 (2020) — The Total and Active Bacterial Community of the Chlorolichen Cetraria islandica and Its Response to Long-Term Warming in Sub-Arctic Tundra. · Frontiers in microbiology
12.PMID: 11849836 (2002) — Determination of antioxidant activity of lichen Cetraria islandica (L) Ach. · Journal of ethnopharmacology
13.PMID: 3468923 (1986) — Toxicity of Iceland lichen and reindeer lichen. · Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
14.PMID: 23833245 (2015) — The effects of Cetraria islandica and Pseudevernia furfuracea extracts in normal and diabetic rats. · Toxicology and industrial health
16.PMID: 24590925 (2014) — Evaluation of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities of lichen Cetraria islandica. · Cytotechnology
17.PMID: 8980785 (1997) — In vitro susceptibility of Helicobacter pylori to protolichesterinic acid from the lichen Cetraria islandica. · Antimicrobial agents and chemotherapy
18.PMID: 24193057 (2016) — The biochemical and histological effects of lichens in normal and diabetic rats. · Toxicology and industrial health
19.PMID: 38233688 (2024) — Non-photochemical quenching may contribute to the dominance of the pale mat-forming lichen Cladonia stellaris over the sympatric melanic Cetraria islandica. · Oecologia
20.PMID: 40807358 (2025) — Cyclodextrin-Based Systems of Cetraria islandica Extracts: A Novel Approach to Improve Solubility and Biological Activity of Lichen-Derived Natural Products. · Molecules (Basel, Switzerland)
21.PMID: 23195981 (1998) — Immunomodulating polysaccharides from aqueous extracts of Cetraria islandica (Iceland moss). · Phytomedicine : international journal of phytotherapy and phytopharmacology
22.PMID: 24660683 (2014) — Antitrypanosomal activity & docking studies of isolated constituents from the lichen Cetraria islandica: possibly multifunctional scaffolds. · Current topics in medicinal chemistry
23.PMID: 7646581 (1995) — Rational approach to fractionation, isolation, and characterization of polysaccharides from the lichen Cetraria islandica. · Arzneimittel-Forschung
24.PMID: 30031897 (2018) — β-1,3/1,4-Glucan Lichenan from Cetraria islandica (L.) ACH. induces cellular differentiation of human keratinocytes. · Fitoterapia
25.PMID: 33804278 (2021) — Diversity and Physiological Characteristics of Antarctic Lichens-Associated Bacteria. · Microorganisms
26.PMID: 28882460 (2018) — Elemental and radiological characterization of commercial Cetraria islandica (L.) Acharius pharmaceutical and food supplementation products. · The Science of the total environment