PubMed-compiled information sheet
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Compiled from 21 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Methanolic root extract (50 mg/kg) reduced blood glucose by up to 58.84% and promoted pancreatic beta-cell regeneration in diabetic rats [PMID:30636828]. Polyphenol leaf extract (150-300 mg/kg) reversed dexamethasone-induced hyperglycemia in rats [PMID:26215014].
Methanol root extract (200-400 mg/kg) protected rats in MES, PTZ, and INH-induced convulsion models [PMID:27379268].
Methanol extract (400 mg/kg) significantly reduced total cholesterol and triglycerides in triton WR-1339-induced and high-fat diet animals [PMID:21591834]. Active sub-fractions from leaves decreased lipid accumulation and body weight gain in HFD-induced obese mice [PMID:26602455].
Polyphenolic leaf extract increased the lifespan of animals with murine Ehrlich ascites carcinoma by 53.41% to 73.95% [PMID:17704739]. Root extracts and isolated triterpenes showed cytotoxicity against MCF-7, BEL-7402, SPC-A-1, and SGC-7901 cancer cell lines [PMID:24374448].
Root-derived phyto-steroids demonstrated anti-inflammatory and analgesic efficacy in vitro and in vivo [PMID:30217788].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 37615387 (2024) — Phytochemical profiling and evaluation of the antidiabetic potential of Ichnocarpus frutescens (Krishna Sariva): kinetic study, molecular modelling, and free energy approach. · Journal of biomolecular structure & dynamics
- 2.PMID: 30636828 (2018) — Antidiabetic potential of active fraction obtained from methanolic extract of Ichnocarpus frutescens: A possible herbal remedy. · Indian journal of pharmacology
- 3.PMID: 27379268 (2014) — Ichnocarpus frutescens Ameliorates Experimentally Induced Convulsion in Rats. · International scholarly research notices
- 4.PMID: 21264156 (2008) — Antidiabetic activity of aqueous root extract of Ichnocarpus frutescens in streptozotocin-nicotinamide induced type-II diabetes in rats. · Indian journal of pharmacology
- 5.PMID: 23961196