This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Inula japonica Thunb. is a medicinal plant used in traditional Chinese and Korean medicine, primarily recognized for its anti-inflammatory, antioxidant, and respiratory therapeutic effects [PMID:33961997, 38457106].
Background
Inula japonica Thunb. (also known as Flos inulae or Xuan Fu Hua) is a plant of the Asteraceae family included in the Chinese Pharmacopoeia (2020 edition) [PMID:33961997]. It is widely distributed across Asia and is used as a botanical medicine in China and Korea [PMID:33961997].
Traditional uses
In traditional Chinese medicine, it is used for water removal, reduction in nausea, prevention of vomiting, and the treatment of cold-related coughs, sputum, wheezing coughs, belching, and other related diseases [PMID:33961997]. It is also used to treat inflammatory diseases [PMID:35034149].
Active compounds
The plant contains a diverse array of sesquiterpenoids, including sesquiterpene lactone dimers such as Japonicone A [PMID:35034149, 24387187], neojaponicone B, and inulanolide E [PMID:25617784]. Other identified compounds include alantolactone, isoalantolactone [PMID:24288468], britanin [PMID:37732549], eupatin [PMID:37298159], and phenolic acids such as caffeoylglucaric and caffeoylquinic acids [PMID:40407292]. Flavonoids (e.g., quercetin, kaempferol) and polysaccharides (e.g., IJP70-1) are also present [PMID:30156801, 37364807].
Mechanism of action
Mechanisms include the suppression of neuroinflammation and recovery of HPA-axis dysfunction [PMID:38457106], inhibition of the JAK-STAT signaling pathway in airway inflammation [PMID:39854818], and downregulation of the SRC/EGFR/MAPK signaling pathway via PKC-α targeting [PMID:40480001]. It also acts by inhibiting soluble epoxide hydrolase (sEH) to ameliorate pulmonary fibrosis [PMID:32663670, 36150346] and suppressing MAPK/NF-κB and activating Keap1/Nrf2 pathways to reduce oxidative stress [PMID:36617177].
Clinical evidence
Evidence DDepression
Inulae Flos demonstrated anti-depressive effects by suppressing neuroinflammation and recovering HPA-axis dysfunction in mice models [PMID:38457106]
Evidence DAsthma/Airway Inflammation
Water extract and ethanol extracts reduced airway hyper-responsiveness, inflammatory cell infiltration, and MUC5AC production in mouse models [PMID:39854818, 37597674, 37960252]
Evidence DPulmonary Fibrosis
Extracts significantly restored lung function and decreased collagen deposition by inhibiting soluble epoxide hydrolase in bleomycin-induced mouse models [PMID:32663670]
Evidence DAcute Lung Injury (ALI)
Alleviated inflammation and oxidative stress by inactivating MAPK/NF-κB and activating Keap1/Nrf2 pathways in LPS-induced mice [PMID:36617177, 36150346]
Evidence DCancer
Sesquiterpene lactones and polysaccharides showed cytotoxic and anti-tumor activities against various cell lines (e.g., HepG2, SMMC-7721) and in zebrafish models [PMID:24387187, 36999317, 37364807]
Evidence D
Safety & adverse effects
Alantolactone and isoalantolactone have been reported to have no significant toxicity [PMID:24288468].
Drug interactions
Xuan-Fu-Hua decoction significantly increased the growth inhibition and apoptosis of liver cancer cells when co-administered with 5-fluorouracil (5-FU) [PMID:35966306].
Evidence summary
The current evidence is primarily based on in vitro cell studies and in vivo animal models (mice, zebrafish), indicating strong pharmacological potential for anti-inflammatory and anti-fibrotic activities, but lacks human clinical trial data.
PubMed sources
1.PMID: 38457106 (2024) — Inulae Flos has Anti-Depressive Effects by Suppressing Neuroinflammation and Recovering Dysfunction of HPA-axis. · Molecular neurobiology
2.PMID: 40480001 (2025) — 1-O-Acetylbritannilactone exerts anti-inflammatory and anti-MUC5AC effects by targeting PKC-α and downregulating the SRC/EGFR/MAPK signaling pathway. · International immunopharmacology
3.PMID: 33961997 (2021) — A review of the botany, traditional uses, phytochemistry, and pharmacology of the Flos Inulae. · Journal of ethnopharmacology
4.PMID: 35966306 (2022) — Transcriptomic and network pharmacology approaches revealed possible mechanisms underlying the 5-fluorouracil (5-FU)-sensitizing effect of Xuan-Fu-Hua decoction treatment on liver cancer cells. · Translational cancer research
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Britanin inhibited osteoclast differentiation and titanium wear particle-induced osteolysis in vivo [PMID:37732549]
Evidence DCOVID-19 (Viral Replication)
Eupatin isolated from flowers inhibited the coronavirus 3CL protease and viral replication in vitro [PMID:37298159]
(2014)
— Inula sesquiterpenoids: structural diversity, cytotoxicity and anti-tumor activity.
· Expert opinion on investigational drugs
6.PMID: 39854818 (2025) — Inula japonica Thunb. and its active compounds ameliorate airway inflammation by suppressing JAK-STAT signaling. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
7.PMID: 35034149 (2022) — Japonicone A and related dimeric sesquiterpene lactones: molecular targets and mechanisms of anticancer activity. · Inflammation research : official journal of the European Histamine Research Society ... [et al.]
8.PMID: 40407292 (2025) — Caffeoylglucaric and Caffeoylquinic Acids from Inula japonica Leaves and Their Anti-Skin Aging Effects in TNF-α-Induced Normal Human Fibroblast Damage. · Journal of agricultural and food chemistry
9.PMID: 37597674 (2024) — Chemical constituents from the flowers of Inula japonica and their anti-inflammatory activity. · Journal of ethnopharmacology
11.PMID: 41577287 (2026) — Discovery of and mechanistic insights into anti-inflammatory sesquiterpenoids from flowers of Inula japonica Thunb. · Phytochemistry
13.PMID: 30156801 (2016) — [Chemical Constituents of Inula japonica]. · Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
14.PMID: 24288468 (2013) — Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone. · TheScientificWorldJournal
15.PMID: 33848587 (2021) — Neolinulicin A and B from Inula japonica and their anti-inflammatory activities. · Fitoterapia
16.PMID: 37732549 (2023) — Britanin inhibits titanium wear particle‑induced osteolysis and osteoclastogenesis. · Molecular medicine reports
17.PMID: 36999317 (2023) — Cytotoxic Terpenes from the Flowers of Inula japonica against Human Hepatocarcinoma Cells. · Chemistry & biodiversity
18.PMID: 37298159 (2023) — Eupatin, a Flavonoid, Inhibits Coronavirus 3CL Protease and Replication. · International journal of molecular sciences
19.PMID: 42343846 (2026) — [Hypolipidemic activity of phenolic acids from Inula japonica Thunb]. · Nan fang yi ke da xue xue bao = Journal of Southern Medical University
20.PMID: 38176376 (2024) — Identification of diverse sesquiterpenoids with anti-fibrotic potential from Inula japonica Thunb. · Bioorganic chemistry
21.PMID: 38276557 (2024) — Anti-Fibrosis Effect of Panax ginseng and Inula japonica Formula in Human Pulmonary Fibroblasts. · Nutrients
22.PMID: 36617177 (2023) — Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways. · The Journal of pharmacy and pharmacology
23.PMID: 27452450 (2016) — Bioactive sesquiterpenoids from the flowers of Inula japonica. · Phytochemistry
24.PMID: 24754174 (2014) — [Anti-inflammatory constituents from Inula japonica]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
25.PMID: 36150346 (2022) — Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics. · Phytomedicine : international journal of phytotherapy and phytopharmacology
26.PMID: 34009074 (2022) — Anti-inflammatory sesquiterpene dimers and diterpenes from the aerial part of Inula japonica. · Journal of Asian natural products research
27.PMID: 37364807 (2023) — A polysaccharide from Inula japonica showing in vivo antitumor activity by interacting with TLR-4, PD-1, and VEGF. · International journal of biological macromolecules
28.PMID: 40864793 (2025) — Protective Effects of Inula japonica Leaf Extract Against PM10-Induced Oxidative Stress in Human Keratinocytes. · Current issues in molecular biology
29.PMID: 37960252 (2023) — Ethanol Extracts from the Aerial Parts of Inula japonica and Potentilla chinensis Alleviate Airway Inflammation in Mice That Inhaled Particulate Matter 10 and Diesel Particulate Matter. · Nutrients
30.PMID: 24754913 (2014) — The genus Inula and their metabolites: from ethnopharmacological to medicinal uses. · Journal of ethnopharmacology