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Jeffersonia diphylla
This herb is NOT recommended during pregnancy due to potential risks to the developing fetus.
This herb is NOT recommended while breastfeeding as effects on infants are unknown.
Consult your healthcare provider before use.
Eastern North American woodland herb related to Berberis; used by Native Americans for rheumatism and syphilis.
Eastern North American woodland herb related to Berberis; used by Native Americans for rheumatism and syphilis. Key active compounds include berberine, alkaloids, tannins.
berberine, along with alkaloids and tannins, are the primary bioactive compounds in Jeffersonia diphylla. These compounds modulates NF-κB and COX-2 inflammatory pathways, disrupts microbial cell membranes and inhibits pathogen growth.
Anti-inflammatory
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Antimicrobial
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Antirheumatic
Rheumatism
Based on traditional use; clinical evidence limited
Syphilis (historical)
Based on traditional use; clinical evidence limited
Fever
Based on traditional use; clinical evidence limited
Wounds
Based on traditional use; clinical evidence limited
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