PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Seed-derived exosomes (CLS-Exos) suppressed ROS, NO, and pro-inflammatory cytokines, ameliorating symptoms in a murine model [PMID:41203172]
Adlay polyphenol (AP) decreased body weight, liver weight, hepatic triglycerides, and serum glucose in high-fat diet-fed mice [PMID:36214059]
Dehulled adlay (DA) was most effective in attenuating plasma glucose, insulin levels, and HOMA-IR in STZ/HFD diabetic rats [PMID:38526822]
Coix sprouts extract inhibited histamine release and IL-31 production, outperforming prednisolone in a mouse model [PMID:39519379]
Ethanolic extracts (AHE-Ea and ATE-Ea) showed dose-dependent growth inhibitory effects and induced apoptosis in human breast (MCF-7) and cervical (HeLa) cancer cell lines [PMID:35807238]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 41203172 (2025) — Emerging nutritional potential of edible-medicinal homologous coix lacryma-jobi seed-derived exosomes for treatment of ulcerative colitis. · International journal of biological macromolecules
- 2.PMID: 24716141 (2012) — Adlay ( yì yĭ; "soft-shelled job's tears"; the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf) is a Potential Cancer Chemopreventive Agent toward Multistage Carcinogenesis Processes. · Journal of traditional and complementary medicine
- 3.PMID: 35707908 (2023) — Two new amides from the seeds of Coix lacryma-jobi var. lacryma-jobi. · Natural product research
- 4.PMID: 36214059 (2022) — Adlay (Coix lacryma-jobi L.) Polyphenol Improves Hepatic Glucose and Lipid Homeostasis through Regulating Intestinal Flora via AMPK Pathway. · Molecular nutrition & food research
- 5.PMID: 35807238