PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Gan Mai Da Zao (GMDZ) decoction, containing jujube, showed mixed results in RCTs; some failed to show favorable effects on response rates in major depression, while others showed benefit in post-surgical depression [PMID:25262476].
A formula of licorice and jujube may improve sleep symptoms, but there is insufficient evidence for clinical recommendations [PMID:34237667].
Ziziphus jujuba var. spinosa seeds are used as a phytomedicine for insomnia and have sedative and sleeping effects [PMID:28084039, PMID:36720435].
Evidence summary
PubMed sources
- 1.PMID: 34128368 (2021) — Research advances in bioactive components and health benefits of jujube (Ziziphus jujuba Mill.) fruit. · Journal of Zhejiang University. Science. B
- 2.PMID: 40580692 (2025) — Gan-Mai-Da-Zao decoction ameliorates depressive-like behaviors in CUMS mice via the microbiota-metabolism-inflammation axis. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 3.PMID: 22414105 (2012) — Nature against depression. · Current medicinal chemistry
- 4.PMID: 39065014 (2024) — Functional Nutrients and Jujube-Based Processed Products in Ziziphus jujuba. · Molecules (Basel, Switzerland)
- 5.PMID: 39679366 (2024) — Phytochemical, pharmacological, pharmacokinetic and toxicological characteristics of Ziziphi Spinosae Semen: a review.