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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Kaempferia galanga is an aromatic medicinal herb native to India and distributed across Asia, used traditionally for various ailments and recognized for its anti-inflammatory and antioxidant properties [PMID:34737693, PMID:32061673].
Background
Kaempferia galanga L., also known as kencur or sand ginger, is a stemless, rhizomatous, aromatic perennial herb of the Zingiberaceae family [PMID:32061673, PMID:36798576]. It is indigenous to India and distributed throughout China, Myanmar, Indonesia, Malaysia, Thailand, Bangladesh, Sri Lanka, Japan, Vietnam, Laos, Sudan, Nigeria, and South Africa [PMID:34737693, PMID:32061673].
Traditional uses
It has been used in Traditional Chinese Medicine and other regional practices to treat cold, dry cough, toothaches, rheumatism, hypertension, fever, headache, skin diseases, arthritis, joint fractures, vertigo, wounds, gastritis, blood vomiting, and mouth sores in infants [PMID:34737693, PMID:32061673, PMID:38286156]. It is also used as a spice, food flavoring, and in cosmetics [PMID:34737693, PMID:32061673].
Active compounds
The rhizome contains ninety-seven identified compounds, including terpenoids, phenolics, cyclic dipeptides, flavonoids, diarylheptanoids, fatty acids, and esters [PMID:34737693]. Key active ingredients include ethyl p-methoxycinnamate (EPMC/EMC), which is the largest active ingredient [PMID:37492546, PMID:37408910], as well as isopimarane diterpenoids and phenylpropanoids [PMID:34636702, PMID:38768796].
Mechanism of action
Anti-inflammatory effects are mediated by limiting leukotriene B4 (LTB4) production [PMID:34765520] and inhibiting NO production and the expression of iNOS and COX-2 [PMID:38768796]. Anti-cancer activity involves suppressing TFAM expression and downregulating cyclin D1 while upregulating p21 [PMID:37408910]. Anti-gout potential is linked to xanthine oxidase inhibitory activity [PMID:29628890].
Clinical evidence
Evidence DOral Mucosal Ulcers
Ethanol extract of K. galanga rhizome (0.5-2%) was effective in increasing recovery of ulcer area and reducing histopathological scores in Wistar rats [PMID:35422649]
Evidence DUlcerative Colitis
Extracellular vesicles derived from rhizomes (KGEVs) showed promising therapeutic effects and targeted enrichment in the colorectal region in vivo [PMID:41350681]
Evidence DDiabetes Mellitus
In vitro analysis showed dose-dependent inhibition of alpha-amylase and alpha-glucosidase activity [PMID:36798576]
Evidence DTraumatic Brain Injury
Ethanolic extract was studied for anti-apoptosis activity through the inhibition of caspase-3 in rat models [PMID:38694581]
Evidence CGout
Identified as having high xanthine oxidase inhibitory activity (>85%) [PMID:29628890]
Safety & adverse effects
While the herb itself is used widely, a mass poisoning event occurred when unprocessed aconite root powders were mislabeled as sand ginger, leading to nausea, vomiting, and ventricular dysrhythmias [PMID:40637172].
Evidence summary
The current evidence consists primarily of in vitro studies, animal models (rats, mice, zebrafish), and literature reviews. There is a lack of human clinical trial data specifically for Kaempferia galanga in the provided abstracts.
PubMed sources
1.PMID: 34737693 (2021) — Kaempferia galanga L.: Progresses in Phytochemistry, Pharmacology, Toxicology and Ethnomedicinal Uses. · Frontiers in pharmacology
2.PMID: 29628890 (2018) — Anti-gout Potential of Malaysian Medicinal Plants. · Frontiers in pharmacology
3.PMID: 38694581 (2024) — Effect of Kencur (Kaempferia galanga L.) Ethanolic Extract Treatment on Cerebral Caspase-3 Expression in Traumatic Brain Injury Rat Models. · The Malaysian journal of medical sciences : MJMS
4.PMID: 32061673 (2020) — Phytochemistry, pharmacological activities and uses of traditional medicinal plant Kaempferia galanga L. - An overview. · Journal of ethnopharmacology
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Extracellular vesicles derived from Kaempferia Galanga L. show promise for targeted oral therapy in the treatment of ulcerative colitis.
· Journal of nanobiotechnology
6.PMID: 31431884 (2019) — Aromatic ginger (Kaempferia galanga L.) extracts with ameliorative and protective potential as a functional food, beyond its flavor and nutritional benefits. · Toxicology reports
7.PMID: 38768796 (2024) — Six new phenylpropanoids from Kaempferia galanga L. and their anti-inflammatory activity. · Fitoterapia
8.PMID: 37492546 (2023) — The dissolution of p-methoxycinnamic acid-β-cyclodextrin inclusion complex produced with microwave irradiation. · Journal of public health in Africa
9.PMID: 36798576 (2022) — An in vitro analysis on the antioxidant and anti-diabetic properties of Kaempferia galanga rhizome using different solvent systems. · Journal of advanced pharmaceutical technology & research
10.PMID: 40637172 (2025) — Mass aconite poisoning from a mislabelled spice product. · Clinical toxicology (Philadelphia, Pa.)
11.PMID: 30699955 (2019) — Complete Chloroplast Genome Sequences of Kaempferia Galanga and Kaempferia Elegans: Molecular Structures and Comparative Analysis. · Molecules (Basel, Switzerland)
12.PMID: 35422649 (2022) — Anti-Inflammatory Activity and Wound Healing Effect of Kaempferia galanga L. Rhizome on the Chemical-Induced Oral Mucosal Ulcer in Wistar Rats. · Journal of inflammation research
13.PMID: 34765520 (2021) — Extract, fractions, and ethyl-p-methoxycinnamate isolate from Kaempferia galanga Elicit anti-inflammatory activity by limiting leukotriene B4 (LTB4) production. · Journal of traditional and complementary medicine
14.PMID: 32436242 (2020) — Clinical trials on pain lowering effect of ginger: A narrative review. · Phytotherapy research : PTR
15.PMID: 38286156 (2024) — Potent anti-angiogenic component in Kaempferia galanga L. and its mechanism of action. · Journal of ethnopharmacology
17.PMID: 37408910 (2023) — Kaempferia galanga L. extract and its main component, ethyl p-methoxycinnamate, inhibit the proliferation of Ehrlich ascites tumor cells by suppressing TFAM expression. · Heliyon
18.PMID: 26014301 (2015) — Study of sedative activity of different extracts of Kaempferia galanga in Swiss albino mice. · BMC complementary and alternative medicine
19.PMID: 36591927 (2022) — Insecticidal and Feeding Deterrent Effects of Kaempferia galanga L. and Amomum subulatum on Pieris rapae L. Larva. · Pakistan journal of biological sciences : PJBS
20.PMID: 38030940 (2023) — Preparation of Self-microemulsion Solids of Kaempferia galanga (L.) Volatile Oil and Its Effect on Rats with Gastric Ulcer. · AAPS PharmSciTech
21.PMID: 41060368 (2025) — Molecular characterization of a proposed novel macluravirus identified in sand ginger (Kaempferia galanga). · Archives of virology
22.PMID: 37023930 (2023) — Diarylheptanoids with hypoglycemic potency from the rhizomes of Kaempferia galanga. · Fitoterapia
23.PMID: 35464179 (2021) — Fermented medicinal herbs improve hematological and physiological profile of Striped catfish (Pangasianodonhypophthalmus). · F1000Research
24.PMID: 35779703 (2022) — Antiviral effect of an extract from Kaempferia galanga L. rhizome in mice infected with pseudorabies virus. · Journal of virological methods
25.PMID: 35101569 (2022) — Wound healing properties of pharmaceutical gel containing isopimarane diterpene isolated from Kaempferia galanga L. · Journal of ethnopharmacology
26.PMID: 36978271 (2022) — Evaluation of Larvicidal Activity of Kaempferia galanga Extracts Against Aedes aegypti Larvae. · Pakistan journal of biological sciences : PJBS
27.PMID: 36819689 (2023) — Chemical composition of the Kaempferia galanga L. essential oil and its in vitro and in vivo antioxidant activities. · Frontiers in nutrition
28.PMID: 32009747 (2019) — Phytogenic compounds do not interfere physiological parameters and growth performances on two Indonesian local breeds of ducks. · Veterinary world
29.PMID: 34636702 (2023) — Isopimarane-type diterpenoids from the rhizomes of Kaempferia galanga L. and their biological activities. · Natural product research
30.PMID: 38543315 (2024) — Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract. · Pharmaceutics