PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Aqueous and ethanolic extracts demonstrated anti-inflammatory and analgesic activities in rats [PMID:23284217]; essential oils suppressed inflammation by 17.60% to 33.57% in mice [PMID:35920490].
Rhizome extracts and essential oils showed inhibitory activity against Gram (+) and Gram (-) bacteria, including methicillin and vancomycin resistant Staphylococcus aureus, as well as fungal cultures [PMID:16530343, PMID:42325443, PMID:28330226].
Ethanolic extract of the rhizome was evaluated for wound healing potential in an excision wound model in rats [PMID:37001768].
Various extracts and isolated compounds (labdane-type diterpenes and sesquiterpenes) demonstrated cytotoxic activity against multiple cancer cell lines, including prostate (PC-3, DU-145), colon, lung, and breast cancer [PMID:36873474, PMID:19027298, PMID:23422227, PMID:34579616].
Aqueous and ethanolic extracts showed dose-dependent anti-histaminic action against histamine-induced bronchospasm in guinea pigs [PMID:23284217].
Evidence summary
PubMed sources
- 1.PMID: 32354114 (2020) — Uncharted Source of Medicinal Products: The Case of the Hedychium Genus. · Medicines (Basel, Switzerland)
- 2.PMID: 29484653 (2018) — Hedychium spicatum: a systematic review on traditional uses, phytochemistry, pharmacology and future prospectus. · The Journal of pharmacy and pharmacology
- 3.PMID: 35790346 (2022) — Synthesis of Sulfur-Containing Analogues of Hedychenone, a Labdane Diterpenoid from Hedychium spicatum. · Journal of natural products
- 4.PMID: 37001768 (2023) — The wound healing potential of Hedychium spicatum Sm. and Zinnia peruviana (L.) ethanolic extracts against excision wound model in rats. · Journal of ethnopharmacology
- 5.PMID: 16530343 (2006)