PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Seed extracts demonstrated neuroprotective activities and improved neurobehavioral activity in mouse and rat models [PMID:35630617, 23562769, 30410229].
Seed extract increased total and free testosterone, FSH, and LH levels in aged rats [PMID:37229277] and reduced sodium arsenite-induced testicular impairment [PMID:36855363].
Ethanolic and aqueous seed extracts resulted in dose-dependent reductions in blood glucose levels in alloxan-induced and STZ-induced diabetic rats [PMID:21914541, 18672037].
Thai M. pruriens seed extract (300 mg/kg) reversed hormonal dysregulation and normalized estrous cyclicity in letrozole-induced PCOS rats [PMID:41950117].
Standardized seed extract showed Angiotensin-converting enzyme (ACE) inhibitory potential [PMID:25868619].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 35630617 (2022) — Mucuna pruriens Seed Aqueous Extract Improved Neuroprotective and Acetylcholinesterase Inhibitory Effects Compared with Synthetic L-Dopa. · Molecules (Basel, Switzerland)
- 2.PMID: 37229277 (2023) — Aging induced testicular damage: analyzing the ameliorative potential of Mucuna pruriens seed extract. · 3 Biotech
- 3.PMID: 39386181 (2024) — Effect of Mucuna pruriens seed extract on depression-like behavior derived from mild traumatic brain injury in rats. · BioMedicine
- 4.PMID: 36855363 (2023) — Ameliorating effect of Mucuna pruriens seed extract on sodium arsenite-induced testicular toxicity and hepato-renal histopathology in rats. · Veterinary world
- 5.PMID: 35662582 (2022)