PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 23 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Ethanolic and chloroform extracts of seeds significantly restored sperm concentration, motility, viability, and serum testosterone levels in cyproterone acetate-induced rat models [PMID:37286756, PMID:31815317]
Methanolic seed extracts, root extracts, and leaf alkaloid fractions showed significant hepatoprotective activity against paracetamol, thioacetamide, and CCl4-induced liver damage in rats [PMID:8824736, PMID:16213687, PMID:20711375]
Aerial part extracts reduced blood glucose and oxidative stress in streptozotocin-induced diabetic rats [PMID:16289604]; flower powder showed antihyperglycemic potential in alloxan-induced diabetic rats [PMID:39926789]
As part of the polyherbal formulation 'Medha Plus', it helped ameliorate cognitive deficits and prevented Aβ-induced loss of neurites and neuronal apoptosis in cellular models [PMID:35617801]
Terpenoid fractions and the compound HA-06 alleviated carrageenan-induced inflammation in rats [PMID:26428681, PMID:39471254]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 30007830 (2018) — Ethnomedicinal, phytochemical and pharmacological updates on Hygrophila auriculata (Schum.) Hiene: an overview. · Journal of integrative medicine
- 2.PMID: 35617801 (2022) — Medha Plus - A novel polyherbal formulation ameliorates cognitive behaviors and disease pathology in models of Alzheimer's disease. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 3.PMID: 37286756 (2023) — Dose-Dependent Protective Effect of Hygrophila auriculata Seeds on Cyproterone Acetate-Induced Testicular Dysfunction. · Reproductive sciences (Thousand Oaks, Calif.)
- 4.PMID: 31815317 (2020) — Protective effect of ethanolic extract of Hygrophila auriculata seeds in cyproterone acetate-induced sexual dysfunction in male albino rats. · Andrologia
- 5.PMID: 34688885