PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
A double-blinded clinical study demonstrated that A. gigas Nakai root extract (ARE) lotion significantly improved anti-wrinkle properties and increased type I collagen production by 40% in vitro [PMID:35460310]
The multi-herbal formula SH003 (containing A. gigas) has shown potential as a chemotherapeutic agent in in vitro and in vivo studies, with a clinical trial performed to identify the maximum tolerated dose in solid cancer patients [PMID:35205836, PMID:40295067]
Methanol extracts of A. gigas root significantly reduced infarction volumes and morphological deterioration in mouse models of stroke [PMID:32983252, PMID:34062098]
A. gigas extract restored diminished vascular relaxation responses to acetylcholine in high fat diet rats [PMID:38095615]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 39128302 (2024) — The multi-herbal decoction SH003 alleviates LPS-induced acute lung injury by targeting inflammasome and extracellular traps in neutrophils. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 2.PMID: 39779619 (2025) — Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy - active Phytochemicals and In Vivo Molecular Targets. · Pharmaceutical research
- 3.PMID: 29215592 (2017) — Natural Korean Medicine Dang-Gui: Biosynthesis, Effective Extraction and Formulations of Major Active Pyranocoumarins, Their Molecular Action Mechanism in Cancer, and Other Biological Activities. · Molecules (Basel, Switzerland)
- 4.PMID: 28452965 (2017) — Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review. · Scientia pharmaceutica
- 5.PMID: 30652050