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Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Korean Bellflower Root (Platycodon grandiflorum) is a medicinal and edible plant used in East Asia, recognized for its respiratory benefits and diverse pharmacological activities [PMID:37047506, PMID:39072195].
Background
Platycodon grandiflorum, also known as balloon flower, is a perennial plant of the Campanulaceae family that grows naturally in Korea, northeastern China, and Japan [PMID:29539882, PMID:23079820]. It is utilized as both a food source and a traditional herbal medicine [PMID:37047506, PMID:36087526].
Traditional uses
In traditional Chinese medicine, it is used to clear the lung, nourish the pharynx, dispel phlegm, discharge pus, tonify the spleen, replenish Qi, relieve cough, clear heat, detoxify, and relieve pain [PMID:38795891, PMID:38171434]. It is traditionally employed for managing respiratory disorders and hepatic metabolic disorders [PMID:40318772, PMID:40395044].
Active compounds
The plant contains 219 chemical constituents, including triterpenoid saponins (platycosides, with platycodin D as a major component), polysaccharides, flavonoids, phenolic acids, polyacetylenes, sterols, fatty acids, and amino acids [PMID:39072195, PMID:36087526, PMID:40848991].
Mechanism of action
Mechanisms include regulation of the TLR4-P2X7r/NLRP3 signaling pathway for pulmonary fibrosis [PMID:40318772], activation of AMPK to attenuate renal ischemia/reperfusion injury [PMID:40848991], and regulation of PPARγ and TLR4/NF-κB signaling for non-alcoholic fatty liver disease [PMID:40395044]. It also increases nitric oxide via G protein-coupled estrogen receptor-mediated eNOS activity to reverse endothelial dysfunction [PMID:40447174].
Clinical evidence
Evidence DAcute Lung Injury (ALI)
Fresh PG effectively improved LPS-induced ALI, reduced inflammatory factors, and relieved lung histopathological injury in mice, showing better efficacy than dried PG [PMID:40186259].
Evidence DTriple-Negative Breast Cancer (TNBC)
Platycodon grandiflorum-derived extracellular vesicles (PGEVs) suppressed TNBC growth by modulating gut microbiota and reversing the immunosuppressive tumor microenvironment [PMID:39920791].
Evidence DPulmonary Fibrosis
PG extracts significantly reduced lung index elevation in cigarette smoke-induced pulmonary fibrosis mice [PMID:40318772].
Platycodin D (PD) alleviated kidney tissue damage and cell apoptosis while reducing ROS levels in diabetic models [PMID:40848991].
Evidence D
Safety & adverse effects
Plant-derived extracellular vesicles from PG exhibit negligible systemic toxicity [PMID:39920791].
Evidence summary
The evidence is primarily based on in vitro studies and animal models (Level D), demonstrating strong potential for respiratory, anti-inflammatory, and metabolic therapeutic applications, though human clinical trials are not detailed in the provided abstracts.
PubMed sources
1.PMID: 40186259 (2025) — Platycodon grandiflorum exosome-like nanoparticles: the material basis of fresh platycodon grandiflorum optimality and its mechanism in regulating acute lung injury. · Journal of nanobiotechnology
2.PMID: 39920791 (2025) — Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gut microbiota. · Journal of nanobiotechnology
3.PMID: 37047506 (2023) — Chromosome-Scale Genome Assembly and Triterpenoid Saponin Biosynthesis in Korean Bellflower (Platycodon grandiflorum). · International journal of molecular sciences
4.PMID: 29539882 (2018) — Analysis of Microbiota in Bellflower Root, Platycodon grandiflorum, Obtained from South Korea. · Journal of microbiology and biotechnology
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PG supplementation suppressed lipid accumulation and inflammatory response in the liver of HFD-induced obese rats [PMID:40395044].
Evidence DDoxorubicin-induced Cardiotoxicity
PG significantly alleviated myocardial damage and prevented cardiomyocyte apoptosis in a mouse model of breast cancer [PMID:37029546].
(2023)
— Biotransformation of Platycosides, Saponins from Balloon Flower Root, into Bioactive Deglycosylated Platycosides.
· Antioxidants (Basel, Switzerland)
6.PMID: 33919900 (2021) — Polyacylated Anthocyanins in Bluish-Purple Petals of Chinese Bellflower, Platycodon grandiflorum. · International journal of molecular sciences
7.PMID: 40318772 (2025) — Ginseng and Platycodon grandiflorum ameliorated pulmonary fibrosis and inflammation targeting TLR4-P2X7r/NLRP3 signaling pathway. · Journal of ethnopharmacology
8.PMID: 32764333 (2020) — Metabolite Profile and Immunomodulatory Properties of Bellflower Root Vinegar Produced Using Acetobacter pasteurianus A11-2. · Foods (Basel, Switzerland)
9.PMID: 39736349 (2025) — Effects and mechanism of combination of Platycodon grandiflorum polysaccharides and Platycodon saponins in the treatment of chronic obstructive pulmonary disease rats through the gut-lung axis. · Journal of ethnopharmacology
10.PMID: 38795891 (2024) — Polysaccharides from Platycodon grandiflorum: A review of their extraction, structures, modifications, and bioactivities. · International journal of biological macromolecules
11.PMID: 40848991 (2025) — Platycodin D attenuates diabetic renal ischemia/reperfusion injury by enhancing mitophagy and suppressing MAPK/NF-κB signaling activation. · Biochimica et biophysica acta. Molecular basis of disease
12.PMID: 38171434 (2024) — Recent advances in Platycodon grandiflorum polysaccharides: Preparation techniques, structural features, and bioactivities. · International journal of biological macromolecules
13.PMID: 40395044 (2025) — Platycodon grandiflorum Attenuates Non-Alcoholic Fatty Liver Disease in Rats Through Regulating Inflammatory Response via PPARγ and TLR4/NF-κB Signaling Pathway. · Biomedical chromatography : BMC
14.PMID: 34361683 (2021) — Phenolic Constituents from Platycodon grandiflorum Root and Their Anti-Inflammatory Activity. · Molecules (Basel, Switzerland)
15.PMID: 39072195 (2024) — Ethnopharmacology, phytochemistry, pharmacology and product application of Platycodon grandiflorum: A review. · Chinese herbal medicines
16.PMID: 23079820 (2012) — Development and characterization of 22 polymorphic microsatellite markers for the balloon flower Platycodon grandiflorum (Campanulaceae). · Genetics and molecular research : GMR
17.PMID: 39072194 (2024) — Biotransformation and pharmacological activities of platycosides from Platycodon grandiflorum roots. · Chinese herbal medicines
18.PMID: 25054103 (2014) — Platycosides from the Roots of Platycodon grandiflorum and Their Health Benefits. · Preventive nutrition and food science
19.PMID: 40629966 (2025) — Structure Characterization and Antibacterial, Antifungal, and Antiquorum-Sensing Activity of New Metabolites From the Lipophilic Fractions of Platycodon grandiflorum Root. · Archiv der Pharmazie
20.PMID: 40769445 (2025) — Platycodon grandiflorum: A promising medicinal and food homologous plant for cigarette smoke-induced chronic bronchitis. · Journal of ethnopharmacology
21.PMID: 31611488 (2019) — Exploration of Root-associated Bacteria from the Medicinal Plant Platycodon grandiflorum. · Microbes and environments
22.PMID: 36087526 (2022) — Platycodon grandiflorum (Jacq.) A. DC.: A review of phytochemistry, pharmacology, toxicology and traditional use. · Phytomedicine : international journal of phytotherapy and phytopharmacology
23.PMID: 9342945 (1997) — Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats. · Planta medica
24.PMID: 25288973 (2013) — Root Rot of Balloon Flower (Platycodon grandiflorum) Caused by Fusarium solani and Fusarium oxysporum. · The plant pathology journal
25.PMID: 42320810 (2026) — Platycodon grandiflorum polysaccharide identified via activity-guided screening: structure, immunostimulatory activity, and glycolysis-mediated mechanism. · International journal of biological macromolecules
26.PMID: 40447174 (2025) — Platycodin D reverses tumor necrosis factor-α-induced endothelial dysfunction by increasing nitric oxide through G protein-coupled estrogen receptor-mediated eNOS activity. · Chemico-biological interactions
27.PMID: 37029546 (2023) — Extract of Platycodon grandiflorum Prevents Doxorubicin-induced Cardiotoxicity in Breast Cancer. · Integrative cancer therapies
28.PMID: 41288460 (2025) — Dietary Saponins as Antiaging Agents: A Systematic Review of Molecular Mechanisms, Nutritional Intervention, and Product Development. · Journal of agricultural and food chemistry
29.PMID: 32573262 (2022) — Isolobetyol, a new polyacetylene derivative from Platycodon grandiflorum root. · Natural product research
30.PMID: 36861146 (2023) — MALDI Imaging Assisted Discovery of a Di-O-glycosyltransferase from Platycodon grandiflorum Root. · Angewandte Chemie (International ed. in English)