PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
C. domestica extracts (1,500 mg/day or 2 g/day) showed significant improvement in WOMAC total, pain, stiffness, and function scores, demonstrating non-inferiority to ibuprofen [PMID:24672232, 19678780]
Curcumin used in conjunction with mainstream therapy (sulfasalazine, mesalamine, or corticosteroids) improved patient symptoms and allowed for a decrease in corticosteroid or 5-ASA dosages [PMID:21649456]
A randomized double-blind trial was conducted to test the efficacy of C. domestica rhizome for acid, flatulent, and atonic dyspepsia [PMID:2699615]
C. domestica has been found to be useful in diabetes associated with ischemic heart disease [PMID:19922253]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 24672232 (2014) — Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. · Clinical interventions in aging
- 2.PMID: 34194529 (2021) — Javanese Turmeric (Curcuma xanthorrhiza Roxb.): Ethnobotany, Phytochemistry, Biotechnology, and Pharmacological Activities. · Evidence-based complementary and alternative medicine : eCAM
- 3.PMID: 11237173 (2000) — Phenolic antioxidants from herbs and spices. · BioFactors (Oxford, England)
- 4.PMID: 29710047 (2018) — Chemical Constituents and Bioactivities of Several Indonesian Plants Typically Used in Jamu. · Chemical & pharmaceutical bulletin
- 5.PMID: 38450269 (2023)