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Lamium Album Herb
Lamium album
leucorrhea and vaginal discharge treatment in European folk medicine
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Lamium album (white dead-nettle) is a medicinal flowering plant used in traditional medicine for its anti-inflammatory, antioxidant, and antimicrobial properties [PMID: 41785535, 26019631].
Background
Lamium album is a perennial wildflower widely distributed across continents, including Eurasia [PMID: 40192867, 37156083]. It belongs to the Lamiaceae family and is closely related to other Lamium species such as L. barbatum [PMID: 41230035].
Traditional uses
Traditional applications include the use of aerial parts and roots in human and veterinary medicine [PMID: 31259737]. It is used to provide relief from pain in rheumatism, vaginal and cervical inflammation [PMID: 30366450], and is recommended for upper respiratory tract disorders or as a topical medication for mild inflammation of the throat, mouth, and skin [PMID: 32283643]. It is also assigned antiseptic, mucolytic, and antispasmodic activities for conditions like chronic bronchitis and pharyngitis [PMID: 28371943, 26019631].
Active compounds
The plant contains iridoids (including lamalbid, shanzhiside methyl ester, and lamiridosins A and B) [PMID: 32283643, 19904996, 30366450], phenylpropanoids (verbascoside, phlinoside D, and acteoside) [PMID: 30366450, 7766391], flavonoids (rutin, quercetin, and tiliroside) [PMID: 32283643, 7766391], and phenolic acids (caffeic, chlorogenic, ferulic, gallic, p-coumaric, protocatechuic, syringic, gentisic, and vanillic acids) [PMID: 33352709]. It also contains sapogenins such as hederagenin and oleanolic acid [PMID: 34946786], as well as magnesium, potassium, and phosphorus [PMID: 40192867].
Mechanism of action
Lamium album extracts have demonstrated the ability to reduce KCl-induced tracheal smooth muscle contraction [PMID: 30151306]. In human neutrophils, certain compounds inhibit the secretion of inflammatory cytokines such as IL-8 and TNF-α [PMID: 30366450]. Additionally, it has shown the ability to scavenge reactive oxygen species (ROS) and decrease nitric oxide (NO) production in human corneal epithelial cells [PMID: 26730306].
Clinical evidence
Evidence BAtopic dermatitis
A tri-herbal combination including Lamium album showed no significant advantage over placebo in objective or subjective parameters [PMID: 15793525]
Evidence BOsteoarthritic pain (base-of-thumb)
Lamium album leaf was used as a placebo and showed significantly less reduction in pain and disability compared to Urtica dioica sting [PMID: 10911825]
Evidence DHaemostasis
Butanolic extracts of L. album demonstrated haemostatic activity in rat models, comparable to vitamin K [PMID: 31259737]
Acute toxicity tests of butanolic extracts in Wistar rats showed no toxicity [PMID: 31259737]. In vitro tests on human corneal epithelial cells showed that extracts did not affect cell viability at concentrations up to 125 μg/ml [PMID: 26730306].
Evidence summary
The evidence consists primarily of in vitro studies and animal models (Level D), with limited clinical trials (Level B) where the herb served as a placebo or part of a combination that showed no superiority over placebo. There is strong phytochemical characterization of its bioactive compounds.
PubMed sources
1.PMID: 31259737 (2019) — Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts. · Acta pharmaceutica (Zagreb, Croatia)
2.PMID: 37999514 (2023) — Lamium album Flower Extracts: A Novel Approach for Controlling Fusarium Growth and Mycotoxin Biosynthesis. · Toxins
3.PMID: 40192867 (2025) — Application of Lamium album Leaves Powder in Wheat Bread Technology. · Plant foods for human nutrition (Dordrecht, Netherlands)
4.PMID: 33352709 (2020) — Phenolic Constituents of Lamium album L. subsp. album Flowers: Anatomical, Histochemical, and Phytochemical Study. · Molecules (Basel, Switzerland)
5.PMID: 41230035 (2025) — Complete chloroplast genomes analysis of Lamium barbatum and Leucas ciliata (Lamiaceae).
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 26730306 (2015) — The Effect of Lamium album Extract on Cultivated Human Corneal Epithelial Cells (10.014 pRSV-T). · Journal of ophthalmic & vision research
7.PMID: 37156083 (2023) — Nectar guides and floral nectary in Lamium album L. subsp. album: structure and histochemistry in light, fluorescence, and electron microscopy. · Micron (Oxford, England : 1993)
8.PMID: 34299441 (2021) — Histochemical and Phytochemical Analysis of Lamium album subsp. album L. Corolla: Essential Oil, Triterpenes, and Iridoids. · Molecules (Basel, Switzerland)
9.PMID: 35851780 (2022) — Potential anti-inflammatory effect of Lamium album extract through caspase-3 and cyclooxygenase-2 genes expression in a rat model of middle cerebral artery occlusion. · Folia medica
10.PMID: 38463484 (2024) — Efficacy of Lamium album as a natural fungicide: impact on seed germination, ergosterol, and mycotoxins in Fusarium culmorum-infected wheat seedlings. · Frontiers in microbiology
11.PMID: 31970022 (2019) — Urtica Dioica and Lamium Album Decrease Glycogen Synthase Kinase-3 beta and Increase K-Ras in Diabetic Rats. · Journal of pharmacopuncture
12.PMID: 7766391 (1995) — Phenylpropanoid esters from Lamium album flowers. · Phytochemistry
13.PMID: 26019631 (2015) — Changes in the functional characteristics of tumor and normal cells after treatment with extracts of white dead-nettle. · Biotechnology, biotechnological equipment
14.PMID: 37765397 (2023) — Use of Secondary Metabolites Profiling and Antioxidant Activity to Unravel the Differences between Two Species of Nettle. · Plants (Basel, Switzerland)
15.PMID: 30366450 (2018) — Bioactive Constituents of Lamium album L. as Inhibitors of Cytokine Secretion in Human Neutrophils. · Molecules (Basel, Switzerland)
16.PMID: 37813985 (2023) — Screening of 20 species from Lamiaceae family based on phytochemical analysis, antioxidant activity and HPLC profiling. · Scientific reports
17.PMID: 41785535 (2026) — Bioactivity profiling of Lamium album by HPTLC combined with effect-directed analysis and high-resolution tandem mass spectrometry. · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
18.PMID: 34946786 (2021) — Separation and Quantification of Selected Sapogenins Extracted from Nettle, White Dead-Nettle, Common Soapwort and Washnut. · Molecules (Basel, Switzerland)
19.PMID: 30151306 (2018) — Effects of standardized extracts of Lamium album and Urtica dioica on rat tracheal smooth muscle contraction. · Journal of pharmacopuncture
20.PMID: 25046755 (2014) — Adaptive changes in photosynthetic performance and secondary metabolites during white dead nettle micropropagation. · Journal of plant physiology
21.PMID: 32283643 (2020) — Lamalbid, Chlorogenic Acid, and Verbascoside as Tools for Standardization of Lamium album Flowers-Development and Validation of HPLC-DAD Method. · Molecules (Basel, Switzerland)
22.PMID: 19904996 (2009) — Lamiridosins, hepatitis C virus entry inhibitors from Lamium album. · Journal of natural products
23.PMID: 40200568 (2025) — Multispectral Imaging Flow Cytometry for Spatio-Temporal Pollen Trait Variation Measurements of Insect-Pollinated Plants. · Cytometry. Part A : the journal of the International Society for Analytical Cytology
24.PMID: 33894742 (2021) — Intraspecific convergence of floral size correlates with pollinator size on different mountains: a case study of a bumblebee-pollinated Lamium (Lamiaceae) flowers in Japan. · BMC ecology and evolution
25.PMID: 10911825 (2000) — Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. · Journal of the Royal Society of Medicine
26.PMID: 36278236 (2022) — In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. · Frontiers in pharmacology
27.PMID: 24311888 (2013) — Antimicrobial activity of extracts from in vivo and in vitro propagated Lamium album L. plants. · African journal of traditional, complementary, and alternative medicines : AJTCAM
28.PMID: 28371943 (2017) — Bioassay-Guided Isolation of Iridoids and Phenylpropanoids from Aerial Parts of Lamium album and Their Anti-inflammatory Activity in Human Neutrophils. · Planta medica
29.PMID: 15793525 (2005) — Treatment of atopic dermatitis with herbal combination of Eleutherococcus, Achillea millefolium, and Lamium album has no advantage over placebo: a double blind, placebo-controlled, randomized trial. · Journal of the American Academy of Dermatology
30.PMID: 41011680 (2025) — Effect of Phenological Stage and Leaf Age on Changes of Chlorophyll and Carotenoid Contents in Some Weeds and Invasive Species. · Molecules (Basel, Switzerland)