PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 25 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Two compounds isolated from root bark showed antiproliferative activity in RPMI 8226, MM.1S, and MM.1R cell lines with IC50 < 5 μM [PMID:36907430]
Ethanolic bark extract prevented bone mass loss and improved bone microarchitecture in ovariectomized Wistar rats [PMID:29279718]
Aqueous or methanol extracts (170 or 340 mg/kg) alleviated reproductive toxicity induced by the insecticide imidacloprid in male rats [PMID:31890217]
Flavonolignan glycosides from the bark displayed inhibitory effects against LmPTR1 [PMID:41418295]
Lannea acida showed no activity in a cytotoxic assay using the HeLa cell line [PMID:20606772]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 36907430 (2023) — Antiproliferative activity of compounds isolated from the root bark of Lannea acida in multiple myeloma cell lines. · Phytochemistry
- 2.PMID: 29279718 (2017) — Lannea acida A. Rich. (Anacardiaceae) Ethanol Extract Exhibits Estrogenic Effects and Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis. · Evidence-based complementary and alternative medicine : eCAM
- 3.PMID: 41418295 (2025) — Flavonolignans from Lannea acida A. Rich. as potential antileishmanial agents. · Natural product research
- 4.PMID: 31890217 (2019) — Colibri® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats. · Basic and clinical andrology
- 5.PMID: 33475981