PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Lavandula x intermedia, known as lavandin, is a sterile hybrid of L. angustifolia and L. latifolia cultivated globally for its essential oils [PMID:25761625, PMID:30083230]. It is utilized in perfumes, cosmetics, and pharmaceuticals, and exhibits various biological activities [PMID:37049706, PMID:40949212].
Background
Lavandula x intermedia (lavandin) is a perennial shrub and a cross hybrid between Lavandula angustifolia and Lavandula latifolia [PMID:30708774, PMID:39035964]. It is characterized by a higher essential oil yield compared to its parent species, though its oil contains more terpenes and camphor notes [PMID:37049706].
Traditional uses
It is traditionally grown in regions such as Croatia as an aromatic and medicinal shrub [PMID:30708774].
Active compounds
The essential oil is rich in monoterpenes and sesquiterpenes [PMID:39035964], with major components including linalool, linalyl acetate, 1,8-cineole, and camphor [PMID:35884108, PMID:41157114]. Other identified compounds include 4-terpineol, borneol, and the sesquiterpene 9-epi-caryophyllene [PMID:32397385, PMID:31349556, PMID:40949212]. Polar bioactive compounds such as rosmarinic acid, ferulic acid glucoside, caffeic acid, morin, coumarin, and herniarin are also present [PMID:35453396, PMID:41730468].
Mechanism of action
Lavandin essential oil exhibits antioxidant activity through free radical scavenging, chelating, and reducing power, likely attributed to linalool and linalyl acetate [PMID:26106980]. It may also demonstrate anti-inflammatory activity via mild inhibition of lipoxygenase, primarily due to linalool and camphor [PMID:26106980].
Clinical evidence
Evidence BPreoperative anxiety
The use of lavandin essential oil was significantly more effective than standard care in reducing anxiety in surgical patients upon transfer to the operating room [PMID:19962101].
Evidence DUVB-induced corneal damage (rat model)
Extracts of L. x intermedia showed a significant reduction in corneal damage and strong antioxidant activity [PMID:41730468].
Evidence summary
Evidence is primarily based on in vitro studies, animal models, and a single randomized controlled trial. While biological activities (antimicrobial, antioxidant, anxiolytic) are suggested, research is described as limited or inconsistent across studies [PMID:37049749].
PubMed sources
- 1.PMID: 37049749 (2023) — Lavandula x intermedia-A Bastard Lavender or a Plant of Many Values? Part II. Biological Activities and Applications of Lavandin. · Molecules (Basel, Switzerland)
- 2.PMID: 37049706 (2023) — Lavandula × intermedia-A Bastard Lavender or a Plant of Many Values? Part I. Biology and Chemical Composition of Lavandin. · Molecules (Basel, Switzerland)
- 3.PMID: 25761625 (2015) — Essential oils and distilled straws of lavender and lavandin: a review of current use and potential application in white biotechnology. · Applied microbiology and biotechnology
- 4.PMID: 40949212 (2025) — Study on the Functional Characterization of 9‑epi-Caryophyllene Synthase from Lavandula x intermedia (Lavandin). · ACS omega
- 5.PMID: 41157114