PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Active compounds
Mechanism of action
Clinical evidence
In testosterone-induced PCOS rats, lemon peel extract (500 mg/kg) was evaluated for effects on TNF-α, HOMA-IR, and fasting blood glucose [PMID:42200096]
Fermented lemon peel filtrate (LMSS4) slowed body weight increase and decreased liver and epididymal fat indices, as well as serum TC, TG, and LDL-C in HFD-induced obese mice [PMID:39968210, PMID:35484880]
Essential oil from C. limon peel inhibited the growth of C. albicans and its biofilm formation in an in vivo rat model [PMID:36398027]
Aqueous methanol extract of lemon peel acted as a preventive and curative agent in experimentally induced hyperoxaluric rats [PMID:26452728]
C. limon peel essential oil gel was administered to diabetic Wistar rats to evaluate the expression of VEGF and CD-31 in traumatic ulcers [PMID:37025967]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 40191954 (2025) — The Persistent Myth of Limonene's Smell. · Chembiochem : a European journal of chemical biology
- 2.PMID: 35406971 (2022) — Functional Anatomy, Impact Behavior and Energy Dissipation of the Peel of Citrus × limon: A Comparison of Citrus × limon and Citrus maxima. · Plants (Basel, Switzerland)
- 3.PMID: 38003150 (2023) — Effect of Lemon (Citrus limon, L.) Peel Powder on Oocyst Shedding, Intestinal Health, and Performance of Broilers Exposed to E. tenella Challenge. · Animals : an open access journal from MDPI
- 4.PMID: 42200096 (2026) — Citrus lemon peel extract versus metformin in testosterone-induced polycystic ovary syndrome: An experimental study. · International journal of reproductive biomedicine
- 5.PMID: 30263826