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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Lepidium sativum, commonly known as garden cress, is an annual herb from the Brassicaceae family used for its nutritional and therapeutic properties [PMID:35937400, PMID:37929722].
Background
Garden cress is a fast-growing annual edible herb native to Egypt and southwest Asia [PMID:37929722]. It is recognized as a healthy vegetable and medicinal plant, with its seeds, leaves, and roots possessing medicinal properties [PMID:35596045, PMID:37929722].
Traditional uses
Historically used in India since the Vedic era to treat respiratory disorders, muscle pain, inflammation, and bone fractures [PMID:37929722]. It has also been utilized for culinary purposes and to treat various liver diseases [PMID:35937400, PMID:33378774].
Active compounds
Key chemical components include flavonoids, alkaloids, cyanogenic glycosides, tannins, glucosinolates, sterols, triterpenes [PMID:35937400], and isothiocyanates (ITCs) [PMID:24510468]. Specific compounds identified include glucotropaeolin and its aglycone benzyl isothiocyanate (BITC) [PMID:33132353], as well as kaempferol glucuronide, gallic acid, protocatechuic acid, coumaric acid, and caffeic acid [PMID:38873486]. Sinapoyl malate is the main UV-absorbing compound in sprout extracts [PMID:34946713].
Mechanism of action
Anti-inflammatory and immunomodulatory effects are associated with the reduction of TNF-α, IL-6, IL-1, NO, iNOS, and HO-1 levels [PMID:35937400]. Isothiocyanates may suppress tumor growth by generating reactive oxygen species or inducing cell cycle arrest leading to apoptosis [PMID:24510468]. In diabetic models, seed oil may abrogate NF-kB-mediated inflammation [PMID:37895159].
Clinical evidence
Evidence DRheumatoid Arthritis
Potential for mitigating rheumatoid arthritis as identified through serum metabolomics and network pharmacology in a rat model [PMID:40890195]
Evidence DAlzheimer's Disease (AlCl3-induced)
Extract administration in rats ameliorated behavioral, biochemical, and cerebral histopathological changes through antioxidant, anti-inflammatory, and antiapoptotic effects [PMID:37077707]
Evidence DHypertension
Combination of L. sativum and amlodipine showed the highest reduction in systolic blood pressure in hypertensive rats [PMID:34958609]
Evidence DHepatic Lipid Accumulation
Glucotropaeolin-rich sprout powder decreased total lipid and triglyceride levels in the liver of mice [PMID:33132353]
Evidence DDiabetic Testicular Injury
Seed oil reduced oxidative injury and NF-kB-mediated inflammation in diabetic mice [PMID:37895159]
Evidence DBacterial Infection (S. aureus)
Pregnancy & lactation
Seeds are considered to be galactagogue [PMID:37929722, PMID:38873486].
Drug interactions
In hypertensive rats, L. sativum combined with amlodipine resulted in a higher reduction of systolic blood pressure compared to amlodipine alone [PMID:34958609].
Evidence summary
The current evidence is primarily based on in vitro studies, animal models (rats, mice), and review articles. There is a lack of human clinical trial data to establish clinical efficacy and safety.
PubMed sources
1.PMID: 29744941 (2018) — Carvacrol and human health: A comprehensive review. · Phytotherapy research : PTR
2.PMID: 35937400 (2022) — Anti-inflammatory and Immunomodulatory Properties of Lepidium sativum. · BioMed research international
3.PMID: 37929722 (2024) — Research Update on the Therapeutic Potential of Garden Cress (Lepidium sativum Linn.) with Threatened Status. · Current drug research reviews
4.PMID: 30067078 (2018) — The natural plant compound carvacrol as an antimicrobial and anti-biofilm agent: mechanisms, synergies and bio-inspired anti-infective materials. · Biofouling
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Seed oil demonstrated antimicrobial activity against Staphylococcus aureus in vitro [PMID:36876662, PMID:35340917]
· Animals : an open access journal from MDPI
6.PMID: 38873486 (2024) — Garden cress seeds: a review on nutritional composition, therapeutic potential, and industrial utilization. · Food science & nutrition
7.PMID: 24418343 (2014) — Lepidium sativum Linn.: a current addition to the family of mucilage and its applications. · International journal of biological macromolecules
8.PMID: 38141653 (2024) — Allelochemical root-growth inhibitors in low-molecular-weight cress-seed exudate. · Annals of botany
9.PMID: 40890195 (2025) — Serum metabolomics-driven network pharmacology elucidate the anti-rheumatoid arthritis potential of garden cress. · Scientific reports
10.PMID: 35596045 (2022) — Construction and characterization of a de novo draft genome of garden cress (Lepidium sativum L.). · Functional & integrative genomics
11.PMID: 33378774 (2021) — A Panoramic Review on Lepidium sativum L. Bioactives as Prospective Therapeutics. · Drug research
12.PMID: 33132353 (2020) — Benzyl Isothiocyanate Produced by Garden Cress (Lepidium sativum) Prevents Accumulation of Hepatic Lipids. · Journal of nutritional science and vitaminology
13.PMID: 35096265 (2022) — Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L. · Oxidative medicine and cellular longevity
14.PMID: 24510468 (2014) — Molecular targets of isothiocyanates in cancer: recent advances. · Molecular nutrition & food research
15.PMID: 40611426 (2026) — Role of Carvacrol in Oral Health: An Overview. · Current pharmaceutical design
16.PMID: 36876662 (2023) — In silico molecular modeling of cold pressed garden cress (Lepidium sativum L.) seed oil toward the binding pocket of antimicrobial resistance Staphylococcus aureus DNA-gyrase complexes. · European review for medical and pharmacological sciences
17.PMID: 30439620 (2019) — Uptake and modification of umbelliferone by various seedlings. · Phytochemistry
18.PMID: 37077707 (2023) — Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects. · Neuropsychiatric disease and treatment
19.PMID: 38227083 (2024) — In vitro chronic phytotoxicity of heavy metals and metalloids to Lepidium sativum (garden cress). · Ecotoxicology (London, England)
20.PMID: 39592037 (2025) — Hydrocolloid-based bioplastics: Degradation in characterized soils. · International journal of biological macromolecules
21.PMID: 40596295 (2025) — Nutritional profiling of foods for Phenylketonuria. · Scientific reports
22.PMID: 34575428 (2021) — Antimicrobial Properties of Lepidium sativum L. Facilitated Silver Nanoparticles. · Pharmaceutics
23.PMID: 36544402 (2022) — Evidence for Health-Promoting Properties of Lepidium sativum L.: An Updated Comprehensive Review. · Turkish journal of pharmaceutical sciences
24.PMID: 34946713 (2021) — Unravelling the Photoprotection Properties of Garden Cress Sprout Extract. · Molecules (Basel, Switzerland)
25.PMID: 36606085 (2023) — Garden cress gum and maltodextrin as microencapsulation coats for entrapment of garden cress phenolic-rich extract: improved thermal stability, storage stability, antioxidant and antibacterial activities. · Food science and biotechnology
26.PMID: 35340917 (2022) — Physicochemical Properties and Biological Activities of Garden Cress (Lepidium sativum L.) Seed and Leaf Oil Extracts. · The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
27.PMID: 37895159 (2023) — Garden Cress Seed Oil Abrogates Testicular Oxidative Injury and NF-kB-Mediated Inflammation in Diabetic Mice. · International journal of molecular sciences
28.PMID: 34958609 (2022) — Herb-drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa. · Xenobiotica; the fate of foreign compounds in biological systems
29.PMID: 35896873 (2022) — 1-Methyl-1H-1,2,4-triazole as the main marker of 1,1-dimethylhydrazine exposure in plants. · Environmental science and pollution research international
30.PMID: 40987802 (2025) — A versatile Lepidium sativum bioassay for use in ecotoxicological studies. · Scientific reports