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PubMed · Neuropharmacological activity of Lippia nodiflora Linn. (2011)
PubMed · Flavonoids and phenylethanoid glycosides from Lippia nodiflora as promising antihyperuricemic agents and elucidation of their mechanism of action. (2015)
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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Lippia nodiflora (also known as Phyla nodiflora) is a perennial creeping herb of the Verbenaceae family with diverse pharmacological properties, including anti-inflammatory, antioxidant, and antihyperuricemic effects [PMID:37869568, PMID:26593216].
Background
Lippia nodiflora (synonym Phyla nodiflora) is a perennial herbaceous plant widely distributed in tropical and subtropical regions [PMID:37869568, PMID:25140335]. It is characterized by exceptional salt tolerance and is used as a pioneer species in ecological restoration [PMID:40623431, PMID:41855960].
Traditional uses
Traditionally used in Ayurvedic, Unani, Sidha, and Traditional Chinese Medicine (TCM) for treating knee joint pain, lithiasis, diuresis, urinary disorders, and swelling [PMID:26593216]. It is also used as a folk medicine in Taiwan for hepatitis and dermatitis [PMID:23304221], as a remedy for ulcers, bronchitis, and heart diseases [PMID:21658378], and by healers in Kerala for treating wounds [PMID:41191869]. Additionally, it is used as an herbal drink and for skin infections [PMID:39149040].
Antihyperuricemic effects are mediated via xanthine oxidase inhibition [PMID:26593216, PMID:26197523]. Antimelanogenesis occurs through the downregulation of tyrosinase activity and reduction of phospho-cAMP response element-binding protein and microphthalmia-associated transcription factor [PMID:23304221, PMID:24212072]. Anti-inflammatory effects may involve the inhibition of lipoxygenase [PMID:26155726] and the Keap1-Nrf2/HO-1 pathway to attenuate oxidative stress [PMID:41494610]. Wound healing may act through the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor resistance pathway [PMID:41191869].
Clinical evidence
Evidence DHyperuricemia
Methanol extract showed a dose-dependent reduction in serum uric acid levels in hyperuricemic rats [PMID:26593216].
Evidence DDiabetes
Oral administration of isolated gamma-sitosterol in STZ-induced diabetic rats significantly decreased blood glucose and glycosylated hemoglobin while increasing plasma insulin [PMID:21658378].
Evidence DInflammation/Pain
Methanolic leaf extract showed significant anti-inflammatory activity comparable to phenylbutazone and antinociceptive activity comparable to diclofenac sodium in rat/mouse models [PMID:15125587].
Evidence DAnxiety/Cognition
Methanolic extract exhibited dose-dependent anxiolytic effects and reversed scopolamine-induced amnesia in rats [PMID:35072654].
Evidence DBreast Cancer (MCF-7)
Leaf and stem extracts induced mitochondrial-dependent apoptosis and cell cycle arrest in human breast cancer cells [PMID:30663 la02].
Evidence D
Safety & adverse effects
Acute toxicity studies on methanol extracts in hyperuricemic rats indicated a safety profile [PMID:26593216]. No toxicity was observed in in vitro or in vivo models during wound-healing studies [PMID:41191869].
Evidence summary
The evidence is primarily based on in vitro cell studies and in vivo animal models (Level D). There are no human clinical trials (RCTs) or systematic reviews provided in the source abstracts.
PubMed sources
1.PMID: 37869568 (2023) — The complete chloroplast genome of Phyla nodiflora (Linnaeus) Greene (1899) from the Verbenaceae family and its phylogenetic analysis. · Mitochondrial DNA. Part B, Resources
2.PMID: 38382345 (2024) — Genome-wide identification of HDAC members and function analysis of PnHDT1/2 in salt stress response in Phyla nodiflora (L.) Greene. · Plant physiology and biochemistry : PPB
3.PMID: 40623431 (2025) — Multi-omics analyses provide insights into the molecular basis for salt tolerance of Phyla nodiflora. · The Plant journal : for cell and molecular biology
4.PMID: 26593216 (2015) — Flavonoids and phenylethanoid glycosides from Lippia nodiflora as promising antihyperuricemic agents and elucidation of their mechanism of action. · Journal of ethnopharmacology
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Eupafolin nanoparticles attenuated LPS-induced acute renal injury in mice by inhibiting oxidative stress and inflammation [PMID:27923689].
(2026)
— Mechanism of salt tolerance in Phyla nodiflora: Insights for coastal vegetation restoration.
· Marine pollution bulletin
6.PMID: 30663402 (2019) — Phyla nodiflora L. Extracts Induce Apoptosis and Cell Cycle Arrest in Human Breast Cancer Cell Line, MCF-7. · Nutrition and cancer
7.PMID: 39149040 (2024) — Chemical composition of organic extracts of Phyla nodiflora L. in Syria by GC-MS. · Heliyon
8.PMID: 23304221 (2012) — Melanogenesis Inhibitor(s) from Phyla nodiflora Extract. · Evidence-based complementary and alternative medicine : eCAM
9.PMID: 22022169 (2011) — Neuropharmacological activity of Lippia nodiflora Linn. · Pharmacognosy research
10.PMID: 24212072 (2014) — Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis: Role of MAPK and Akt pathways. · Journal of ethnopharmacology
11.PMID: 25140335 (2014) — HPLC-fingerprints and antioxidant constituents of Phyla nodiflora. · TheScientificWorldJournal
12.PMID: 21658378 (2011) — Antidiabetic activity of γ-sitosterol isolated from Lippia nodiflora L. in streptozotocin induced diabetic rats. · European journal of pharmacology
13.PMID: 35072654 (2021) — Neuropharmacological investigation, ultra-high performance liquid chromatography analysis, and in silico studies of Phyla nodiflora. · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
14.PMID: 22556775 (1996) — Antibacterial acivity of the essential oil of lippie nodiflora. · Ancient science of life
15.PMID: 34415547 (2021) — An Insilico evaluation of phytocompounds from Albizia amara and Phyla nodiflora as cyclooxygenase-2 enzyme inhibitors. · Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
16.PMID: 41494610 (2026) — Flavonoid-rich Phyla nodiflora fraction promotes Keap1 degradation and Nrf2/HO-1 activation to attenuate particulate matter-induced oxidative stress in human keratinocytes. · Journal of ethnopharmacology
17.PMID: 6876850 (1983) — Anna Pavala Sindhooram--an antiatherosclerotic Indian drug. · Journal of ethnopharmacology
18.PMID: 29268970 (2017) — Pharmacological evaluation of smooth muscle relaxant and cardiac-modulation potential of Phyla nodiflora in ex-vivo and in-vivo experiments. · Asian Pacific journal of tropical medicine
19.PMID: 25709206 (2015) — Hepatoprotective and antibacterial activity of Lippia nodiflora Linn. against lipopolysaccharides on HepG2 cells. · Pharmacognosy magazine
20.PMID: 15125587 (2004) — Anti-inflammatory and antinociceptive activities of Lippia nodiflora Linn. · Die Pharmazie
21.PMID: 37397008 (2023) — Stress mitigation by riparian flora in industrial contaminated area of River Chenab Punjab, Pakistan. · PeerJ
22.PMID: 26155726 (2015) — In vitro, fluorescence-quenching and computational studies on the interaction between lipoxygenase and 5-hydroxy-3',4',7-trimethoxyflavone from Lippia nodiflora L. · Journal of receptor and signal transduction research
23.PMID: 41191869 (2026) — Exploring the Underlying Mechanism of Action of Lippia nodiflora on Wound Healing Based on Network Pharmacology, Molecular Docking, and Experimental Validation. · Chemistry & biodiversity
24.PMID: 41884967 (2026) — Distribution of metals in four spontaneous plants and soils from swales and detention basins along roadways in the Edwards Aquifer recharge zone, Central Texas. · Journal of environmental quality
25.PMID: 10913852 (2000) — Halleridone and Hallerone from Phyla nodiflora as taxonomic markers. · Biochemical systematics and ecology
26.PMID: 12974401 (2002) — In vitro regeneration of roots of Phyla nodiflora and Leptadenia reticulata, and comparison of roots from cultured and natural plants for secondary metabolites. · Indian journal of experimental biology
27.PMID: 26197523 (2015) — In vitro Xanthine Oxidase Inhibitory Studies of Lippia nodiflora and Isolated Flavonoids and Phenylethanoid Glycosides as Potential Uric Acid-lowering Agents. · Natural product communications
28.PMID: 19296386 (2009) — Steroidal constituents from the aerial parts of Lippia nodiflora Linn. · Natural product research
29.PMID: 18254236 (2007) — Chemical constituents from the aerial parts of Lippia nodiflora Linn. · Archives of pharmacal research
30.PMID: 27923689 (2017) — Eupafolin nanoparticle improves acute renal injury induced by LPS through inhibiting ROS and inflammation. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie