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Litsea glutinosa
Litsea glutinosa
Traditional Ayurvedic herb for diarrhea and skin conditions
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Litsea glutinosa is a multipurpose tree from the Lauraceae family with documented analgesic, antidiabetic, and hepatoprotective potentials [PMID:36678501, 38731572, 38302935].
Background
Litsea glutinosa (Lour.) C. B. Robinson is a fast-growing evergreen or deciduous tree belonging to the Lauraceae family [PMID:36678501]. It is found in regions such as North Eastern India and Bangladesh [PMID:21589753, 36567040].
Traditional uses
Traditionally used for the treatment of diarrhea, dysentery, abdominal pain, indigestion, gastroenteritis, edema, traumatic injuries, colds, arthritis, asthma, diabetes, pain relief, and poignant sexual power [PMID:36678501]. In Bangladesh, it is specifically used to treat hepatitis and liver injury [PMID:36567040].
Active compounds
Identified compounds include alkaloids (notably laurolitsine), glycosides, terpenoids [PMID:36678501], phenols, and flavonoids [PMID:39888966]. Specific isolated compounds include flavonoid glycosides (4'-O-methyl (2',4'-di-E-p-coumaroyl) afzelin and quercetin 3), butenolides (litsealactone C, D, and G), and a flavone glycoside named glutin [PMID:38302935, 23495156, 20208374]. Saponins and arabinoxylan have also been isolated [PMID:33182339, 2379194].
Mechanism of action
Antidiabetic effects of laurolitsine are associated with the regulation of the hepatic LKB1-AMPK pathway and gut microbiota [PMID:36075181]. Osteoprotective effects are linked to the promotion of BMP2/SMAD1 signaling, increasing expression of BMP2, PSMAD, RUNX2, and type 1 collagen [PMID:38492310]. Antidiarrheal effects are suggested to involve interactions between imidazole-containing compounds and muscarinic acetylcholine and 5-HT3 receptors [PMID:36791925].
Clinical evidence
Evidence APain/Analgesia
Demonstrated peripheral antinociceptive properties (inhibiting acetic-acid-induced writhing), central analgesic effects at the spinal level (tail flick assay), and supraspinal efficacy (hot plate assay) in animal models [PMID:38731572].
Evidence DDiabetes
Alkaloid-rich bark extract and laurolitsine reduced fasting glucose, HbA1c, and GSP, while improving insulin sensitivity and oral glucose tolerance in ob/ob mice [PMID:30140027, 36075181].
Evidence DDiarrhea
Leaf extract reduced diarrhea in castor oil-induced and magnesium sulfate-induced animal models [PMID:36791925].
Evidence DOsteoporosis/Fracture Healing
Extract increased osteoblast differentiation, viability, and mineralization, and promoted fracture healing in ovariectomized mice [PMID:38492310, 34799209].
Evidence DHepatotoxicity
Leaf methanol extract showed hepatoprotective and antioxidant effects in H2O2-induced HepG2 cells [PMID:36567040].
Evidence D
Safety & adverse effects
An acute toxicity test was conducted to assess the safety profile of leaf extracts, though specific adverse effect data is not detailed in the provided abstracts [PMID:39888966].
Evidence summary
The evidence consists primarily of in vitro cell studies and in vivo animal models (Level D), with one systematic review (Level A) supporting its analgesic potential. No human clinical trials were provided.
PubMed sources
1.PMID: 38731572 (2024) — The Analgesic Potential of Litsea Species: A Systematic Review. · Molecules (Basel, Switzerland)
2.PMID: 36678501 (2022) — Ethnomedicinal Uses, Phytochemistry, and Therapeutic Potentials of Litsea glutinosa (Lour.) C. B. Robinson: A Literature-Based Review. · Pharmaceuticals (Basel, Switzerland)
3.PMID: 38302935 (2024) — Two rare flavonoid glycosides from Litsea glutinosa (Lour.) C. B. Rob.: experimental and computational approaches endorse antidiabetic potentiality. · BMC complementary medicine and therapies
4.PMID: 36567040 (2023) — Hepatoprotective potency of Litsea glutinosa (L.) C.B. Rob. leaf methanol extract on H2O2-induced toxicity in HepG2 cells. · Journal of ethnopharmacology
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
9.PMID: 36075181 (2022) — Laurolitsine ameliorates type 2 diabetes by regulating the hepatic LKB1-AMPK pathway and gut microbiota. · Phytomedicine : international journal of phytotherapy and phytopharmacology
10.PMID: 34799209 (2022) — Molecular insights for an anti-osteoporotic properties of Litsea glutinosa on Saos-2 cells: An in-vitro approach. · Journal of Ayurveda and integrative medicine
11.PMID: 33182339 (2020) — Natural Surfactant Saponin from Tissue of Litsea glutinosa and Its Alternative Sustainable Production. · Plants (Basel, Switzerland)
12.PMID: 36897438 (2023) — Insight study on synthesis and antibacterial mechanism of silver nanoparticles prepared from indigenous plant source of Jharkhand. · Journal, genetic engineering & biotechnology
13.PMID: 40934501 (2025) — Essential Oils From Four Litsea Species of Uttarakhand: Phytochemical Insights and Biological Activities. · Chemistry & biodiversity
14.PMID: 36296555 (2022) — Phytochemical Analysis and Understanding the Antioxidant and Anticancer Properties of Methanol Extract from Litsea glutinosa: In Vitro and In Vivo Studies. · Molecules (Basel, Switzerland)
15.PMID: 23495156 (2013) — Butanolides from methanolic extract of Litsea glutinosa. · Chemistry & biodiversity
16.PMID: 21589753 (2010) — Evaluation of binding property of mucilage from Litsea glutinosa wall. · Pharmacognosy research
17.PMID: 30140027 (2018) — Anti-hyperglycemic and anti-hyperlipidemia effects of the alkaloid-rich extract from barks of Litsea glutinosa in ob/ob mice. · Scientific reports
18.PMID: 34219593 (2021) — Study on the pharmacokinetics, tissue distribution and excretion of laurolitsine from Litsea glutinosa in Sprague-Dawley rats. · Pharmaceutical biology
19.PMID: 39888966 (2025) — Assessment of phytochemical screening, antibacterial, analgesic, and antipyretic potentials of Litsea glutinosa (L.) leaves extracts in a mice model. · PloS one
20.PMID: 2379194 (1990) — Structural studies of an arabinoxylan isolated from Litsea glutinosa (Lauraceae). · Carbohydrate research
21.PMID: 20208374 (2010) — A new 2'-oxygenated flavone glycoside from Litsea glutinosa (Lour.) C. B. Rob. · Bioscience, biotechnology, and biochemistry