PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Chai-hu Long-gu Mu-li decoction (CLMD) is reported to have good curative effects clinically, with network pharmacology and zebrafish experiments identifying 97 dual-effects active compounds and 118 common targets [PMID:40976904]
Patients receiving western anti-tinnitus therapy combined with Chai-Hu-Jia-Long-Gu-Mu-Li-Tang showed significant reductions in Tinnitus Handicap Inventory (THI) and Pittsburgh Sleep Quality Index (PSQI) scores after 2 months [PMID:25847560]
Long-term oral administration of Bushen Tiansui decoction (containing Fossilia Ossis Mastodi) prevented hippocampal synaptic loss and increased expression of synaptic proteins (PSD-95, NMDA receptor 2B subunit, and Shank1) [PMID:29171433]
Evidence summary
PubMed sources
- 1.PMID: 26841944 (2016) — Longgu (Fossilia Ossis Mastodi) alters the profiles of organic and inorganic components in Keishikaryukotsuboreito. · Journal of natural medicines
- 2.PMID: 28220276 (2017) — Taxonomic examination of longgu (Fossilia Ossis Mastodi, "dragon bone") and a related crude drug, longchi (Dens Draconis, "dragon tooth"), from Japanese and Chinese crude drug markets. · Journal of natural medicines
- 3.PMID: 41672119 (2026) — Long Gu (Os Draconis): Textual research, modern scientific evaluation, and quality control challenges. · Journal of ethnopharmacology
- 4.PMID: 30989993 (2019) — [Famous veteran traditional Chinese medicine doctors' medication rules in treating spermatorrhea]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- 5.PMID: 40976904