PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Root extracts exhibited significant antimycobacterial activity against Mycobacterium fortuitum, M. aurum [PMID:18350523], M. smegmatis, and M. bovis BCG [PMID:22899555]. Essential oils showed activity against multidrug-resistant Mycobacterium tuberculosis [PMID:30873267].
In male Wistar rats, Levisticum officinale extract (100-400 mg/kg) attenuated spatial learning and memory impairments induced by lipopolysaccharide (LPS) [PMID:36478529, PMID:32648872].
Extracts exhibited apoptotic and anti-inflammatory properties on HT-29 and Caco-2 human colorectal carcinoma cell lines [PMID:39224551].
Hydroalcoholic extract triggered apoptosis and down-regulated ZNF703 gene expression in MCF-7 and MDA-MB-468 cell lines [PMID:31832434, PMID:37023241].
Aquatic extracts (100-300 ug/mL) prevented lipid peroxidation and reduction in mitochondrial membrane potential in hepatocytes exposed to paraquat [PMID:29188770].
Safety & adverse effects
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 36676932 (2022) — Coumarins of Lovage Roots (Levisticum officinale W.D.J.Koch): LC-MS Profile, Quantification, and Stability during Postharvest Storage. · Metabolites
- 2.PMID: 36478529 (2023) — Treadmill running and Levisticum Officinale extract protect against LPS-induced memory deficits by modulating neurogenesis, neuroinflammation and oxidative stress. · Metabolic brain disease
- 3.PMID: 18350523 (2008) — Antimycobacterial polyacetylenes from Levisticum officinale. · Phytotherapy research : PTR
- 4.PMID: 22899555 (2013) — Antimycobacterials from lovage root (Ligusticum officinale Koch). · Phytotherapy research : PTR
- 5.PMID: 39224551 (2024) — Anti-inflammatory and Apoptotic Effects of Levisticum Officinale Koch Extracts on HT 29 and Caco-2 Human Colorectal Carcinoma Cell Lines.