PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Chinese herbal prescriptions containing velvet antler plus mifepristone reduced uterine fibroid volume more than mifepristone alone [PMID:34488366]
In animal models, water extract of Cervus elaphus sibiricus led to earlier union of fractured bones [PMID:39833827]; polypeptides showed anti-osteoporotic effects in ovariectomized rats [PMID:23993908].
A systematic review of 7 RCTs found that most trials showed no effect, and two reported some positive effects that were not convincing [PMID:23321886]
Velvet antler polypeptides (VAP) demonstrated protective effects against D-galactose-induced aging in mouse models [PMID:40618823]
Safety & adverse effects
Pregnancy & lactation
Evidence summary
PubMed sources
- 1.PMID: 37555852 (2024) — Well-known polypeptides of deer antler velvet with key actives: modern pharmacological advances. · Naunyn-Schmiedeberg's archives of pharmacology
- 2.PMID: 36833351 (2023) — MiRNA Profiling and Its Potential Roles in Rapid Growth of Velvet Antler in Gansu Red Deer (Cervus elaphus kansuensis). · Genes
- 3.PMID: 25319223 (2014) — The contribution of deer velvet antler research to the modern biological medicine. · Chinese journal of integrative medicine
- 4.PMID: 40618823 (2025) — Effects of polypeptides derived from velvet antler on D-gal induced brain aging model. · International journal of biological macromolecules
- 5.PMID: 39833827 (2025)