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Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Ludwigia octovalvis is an aquatic plant used in traditional medicine for conditions such as diabetes, hypertension, and wound management [PMID:28666833, 37447139, 39345301].
Background
Ludwigia octovalvis (also known as willow primrose) is a globally distributed wetland plant belonging to the Onagraceae family [PMID: 27856583, 28695387].
Traditional uses
Historically consumed as a healthful drink for treating edema, nephritis, hypotension, diabetes, dysentery, diarrhea, and headache [PMID: 28666833, 26091966, 22705121]. It is also used traditionally in parts of Asia for wound management [PMID: 39345301] and as a diuretic [PMID: 19963029].
Active compounds
The plant contains oleanane-type triterpenes including (23Z)-feruloylhederagenin, (23E)-feruloylhederagenin, beta-amyrin acetate, and beta-amyrin palmitate [PMID: 17365192], as well as (23Z)-coumaroylhederagenin, (23E)-coumaroylhederagenin, (3Z)-coumaroylhederagenin, oleanolic acid, and ursolic acid [PMID: 14738395]. Other identified constituents include chlorophyll a [PMID: 19963029], polyphenols, flavonoids [PMID: 24338263], beta-sitosterol, 2alpha-hydroxy ursolic acid, tormentic acid, daucosterol, maltol, luteolin, quercetin, apigenin, methyl brevifolincarboxylate, gallic acid, and ellagic acid [PMID: 16494025].
Mechanism of action
Chlorophyll a from L. octovalvis activates the CD95 (APO-1/CD95) system and AMPK pathway in 3T3-L1 cells [PMID: 19963029]. Extracts may regulate lifespan through a dietary restriction (DR)-related pathway and activate AMPK [PMID: 24338263, 28666833]. The plant also contains compounds capable of inhibiting digestive enzymes, including alpha-amylase, alpha-glucosidase, lipase, and pepsin [PMID: 37835184, 30105075].
Clinical evidence
Evidence DDiabetes/Hyperglycemia
Extracts improved glycemic control in streptozotocin-induced and high fat diet-induced diabetic mice [PMID: 28666833] and decreased fasting glycemia in a murine model of metabolic syndrome [PMID: 37447139].
Evidence DCognitive Decline/Memory
Extracts attenuated age-related memory deficits in Drosophila melanogaster and SAMP8 mice [PMID: 24338263, 28666833].
Evidence DMetabolic Syndrome/Obesity
Hydroalcoholic extract and ethyl acetate fraction significantly decreased body weight gain, systolic and diastolic blood pressure, and insulin resistance (TyG index) in hypercaloric diet mice [PMID: 37447139].
Evidence DExercise Performance
Oral administration in mice dose-dependently increased endurance swimming time and increased gastrocnemius muscle glycogen content [PMID: 29962382].
Evidence DWound Healing
Ethanolic extract was investigated for wound healing potential using an excision wound model in Sprague-Dawley rats [PMID: 39345301].
Evidence D
Safety & adverse effects
In an acute toxicity study in BALB/c mice, a single oral dose of 5000 mg/kg showed no mortality or toxic symptoms over 14 days [PMID: 22705121]. Subacute toxicity (up to 800 mg/kg daily for 28 days) was also evaluated [PMID: 22705121].
Evidence summary
The evidence is primarily based on in vitro studies and animal models (mice, rats, and Drosophila), indicating potential anti-hyperglycemic, anti-obesity, and neuroprotective effects. No human clinical trials were provided.
PubMed sources
1.PMID: 17365192 (2007) — Oleanane-type triterpenes from Ludwigia octovalvis. · Journal of Asian natural products research
3.PMID: 28666833 (2017) — Ludwigia octovalvis extract improves glycemic control and memory performance in diabetic mice. · Journal of ethnopharmacology
4.PMID: 24338263 (2014) — The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice. · Age (Dordrecht, Netherlands)
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Screening of Formosan plant drugs showed significant antihepatotoxic activity against cytotoxicity produced by carbon tetrachloride and D-galactosamine [PMID: 3586694].
Evidence DImmune Response
Methanolic extract significantly increased IgA serum levels in Balb/c mice following E. coli O157:H7 infection [PMID: 26091966].
— Chemical Characterization, Antilipidemic Effect and Anti-Obesity Activity of Ludwigia octovalvis in a Murine Model of Metabolic Syndrome.
· Plants (Basel, Switzerland)
6.PMID: 39345301 (2024) — Wound Healing and Acute Dermal Toxicity Studies of Ludwigia octovalvis (Jacq.) P. H. Raven (Onagraceae) in Sprague-Dawley Rats. · Journal of tropical medicine
7.PMID: 3586694 (1987) — Antihepatotoxic actions of Formosan plant drugs. · Journal of ethnopharmacology
8.PMID: 29962382 (2019) — Ludwigia octovalvis (Jacq.) raven extract supplementation enhances muscle glycogen content and endurance exercise performance in mice. · The Journal of veterinary medical science
9.PMID: 26091966 (2015) — Immune-stimulating properties of 80% methanolic extract of Ludwigia octovalvis against Shiga toxin-producing E. coli O157:H7 in Balb/c mice following experimental infection. · Journal of ethnopharmacology
10.PMID: 22705121 (2012) — Toxicological evaluation of 80% methanol extract of Ludwigia octovalvis (Jacq.) P.H. Raven leaves (Onagraceae) in BALB/c mice. · Journal of ethnopharmacology
11.PMID: 19963029 (2010) — Chlorophyll a, an active anti-proliferative compound of Ludwigia octovalvis, activates the CD95 (APO-1/CD95) system and AMPK pathway in 3T3-L1 cells. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
12.PMID: 30105075 (2018) — Identification of Digestive Enzyme Inhibitors from Ludwigia octovalvis (Jacq.) P.H.Raven. · Evidence-based complementary and alternative medicine : eCAM
13.PMID: 14738395 (2004) — Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines. · Journal of natural products
14.PMID: 23082084 (2012) — In vitro screening of medicinal plants used in Mexico as antidiabetics with glucosidase and lipase inhibitory activities. · Evidence-based complementary and alternative medicine : eCAM
15.PMID: 27856583 (2016) — Complete Plastome Sequence of Ludwigia octovalvis (Onagraceae), a Globally Distributed Wetland Plant. · Genome announcements
16.PMID: 16494025 (2005) — [Studies on the chemical constituents in herb of Ludwigia octovalvis]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica