PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Bark extracts and specific lignans ((+)-galbelgin and meso-dihydroguaiaretic acid) significantly inhibited TSLP/TSLPR interaction and STAT5 phosphorylation in human mast cells [PMID: 34443392]
Topical treatment in hairless mice decreased skin/epidermis thickness and MDA levels while increasing SOD levels [PMID: 20127882]
Lignans including isoguaiacin, meso-dihydroguaiaretic acid, licarin A, and (+)-guaiacin protected rat cortical cells against glutamate-induced neurotoxicity [PMID: 14765301]
(-)-Acuminatin, (-)-isoguaiacin, and meso-dihydroguaiaretic acid reduced glutamic pyruvic transaminase release and preserved glutathione, SOD, glutathione peroxidase, and catalase in CCl4-injured rat hepatocytes [PMID: 11045899]
Arylnaphthalene type lignans (guaiacin, isoguaiacin, and isoguaiacin dimethylether) increased alkaline phosphatase activity, collagen synthesis, and calcium deposition in mouse osteoblasts [PMID: 17409528]
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 34443392 (2021) — Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors. · Molecules (Basel, Switzerland)
- 2.PMID: 37965621 (2023) — Dataset on the compounds from the leaves of Vietnamese Machilus thunbergii and their anti-inflammatory activity. · Data in brief
- 3.PMID: 35038992 (2022) — More opportunities more species: Pleistocene differentiation and northward expansion of an evergreen broad-leaved tree species Machilus thunbergii (Lauraceae) in Southeast China. · BMC plant biology
- 4.PMID: 20127882 (2010) — Effects of Machilus thunbergii Sieb et Zucc on UV-induced photoaging in hairless mice. · Phytotherapy research : PTR
- 5.PMID: 26055126 (2015)