PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Attenuated renal injury by reducing blood urea nitrogen levels and morphological changes, and reduced inflammation by inhibiting TNF-α, IL-1β, and IL-6 in mice [PMID:40365315]
Dose-dependent reduction in alveolar bone loss (decreased CEJ-ABC distance) and reduced furcation involvement in rats [PMID:41614939]; inhibited NO production and pro-inflammatory cytokines in vitro [PMID:36661522, 37367059]
Improved neointimal formation by regulating ferroptosis and VSMC phenotypic switching in a carotid artery ligation mouse model [PMID:39754271]
Enhanced osteoblast differentiation and mineralization while inhibiting osteoclast differentiation in vitro [PMID:41828688]
Suppressed ear swelling in a mouse model and inhibited LPS-induced NO and IL-1beta in macrophage cells [PMID:18521967]
Evidence summary
PubMed sources
- 1.PMID: 40365315 (2025) — Magnolia kobus DC. Alleviates adenine-induced chronic kidney disease by regulating ferroptosis in C57BL/6 mice. · Frontiers in pharmacology
- 2.PMID: 41828688 (2026) — Novel Osteoblastogenic Activity of Magnolia kobus: The Pharmacological Potential for Osteoporosis. · International journal of molecular sciences
- 3.PMID: 36661522 (2023) — Magnolia kobus Extract Inhibits Periodontitis-Inducing Mediators in Porphyromonas gingivalis Lipopolysaccharide-Activated RAW 264.7 Cells. · Current issues in molecular biology
- 4.PMID: 39759825 (2024) — Magnolia kobus DC. Regulates Vascular Smooth Muscle Cell Proliferation by Modulating O-GlcNAc and MOF Expression. · Preventive nutrition and food science
- 5.PMID: 39754271