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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Mentha longifolia, also known as horse mint or wild mint, is a diploid aromatic plant used traditionally for various therapeutic purposes and as a source of essential oils [PMID:32188234, PMID:41174465, PMID:25284948].
Background
Mentha longifolia is a wild, diploid mint species that serves as an ancestral parent to cultivated spearmint (Mentha spicata) [PMID:39516760, PMID:41174465, PMID:27867107]. It is widely distributed and used as a model for genomic research regarding essential oil traits and resistance to Verticillium wilt [PMID:35551385, PMID:34834841].
Traditional uses
Traditionally consumed as herbal tea in Europe, Australia, and North Africa [PMID:32116670]. It has been used to treat gastrointestinal disorders, respiratory disorders, infectious diseases, inflammatory diseases, and menstrual disorders [PMID:32188234]. In Lebanon, it is used as an indigenous antihypertensive remedy [PMID:31330767].
Active compounds
Key constituents include pulegone (identified as a main compound), menthone, isomenthone, menthol, 1,8-cineole, borneol, and piperitenone [PMID:25284948, PMID:41456269]. Other bioactive components include flavonoids, phenolic acids, cinnamates, ceramides, sesquiterpenes, terpenes, terpenoids [PMID:32188234], chalcone glycosides [PMID:25429992], and triterpenic compounds such as ursolic acid, oleanolic acid, and rosmarinic acid [PMID:42336988].
Mechanism of action
The plant may exert nephroprotective effects via the regulation of reactive oxygen species (ROS) [PMID:34716886]. It has demonstrated the ability to decrease cardiac load and alleviate declines in cardiac contractility in experimental angina models [PMID:31353642].
Clinical evidence
Evidence BMild Hypertension
Tested in a randomized, blind, placebo-controlled trial in 29 subjects; however, the provided abstract does not state the final outcome of the antihypertensive capacity [PMID:31330767]
Evidence AFunctional Dyspepsia
Included as one of 15 herbs in Persian clinical trials reviewed for effectiveness in treating functional dyspepsia [PMID:32525777]
Evidence DAdrenocortical Carcinoma
Crude extract showed antiproliferative effects in H295R and SW13 tumor cell models, inducing both necrotic and apoptotic cells [PMID:32116670]
Evidence DDiabetic Hypoglycemia/Renal Toxicity
Methanolic extract rescued impaired redox defense, abnormal kidney histopathology, and liver toxicity markers in rat models [PMID:34716886]
Evidence DAngina
Extract significantly alleviated sustained decline in cardiac contractility and decreased heart rate after vasopressin exposure in rats [PMID:31353642]
Evidence D
Safety & adverse effects
The plant may exert toxic effects in different systems of the body depending on the dose [PMID:25284948].
Evidence summary
Evidence is primarily based on in vitro studies, animal models (D), and a few reviews (C). There is limited clinical data, including one systematic review of Persian trials (A) and one small RCT (B) regarding hypertension.
PubMed sources
1.PMID: 39516760 (2024) — Chromosome-scale assembly of apple mint (Mentha suaveolens). · BMC genomic data
2.PMID: 32188234 (2017) — Pharmacological activity of Mentha longifolia and its phytoconstituents. · Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
3.PMID: 33776756 (2020) — Ethnomedicinal Plants of Hasankeyf (Batman-Turkey). · Frontiers in pharmacology
4.PMID: 33294657 (2020) — Characterization, activities, and ethnobotanical uses of Mentha species in Morocco. · Heliyon
5.PMID: 37323050 (2023) — Non-Chinese herbal medicines for functional dyspepsia. · The Cochrane database of systematic reviews
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Essential oil exhibited antifungal activity with inhibition zones ranging from 9-14 mm [PMID:41456269]
6.PMID: 41174465 (2025) — Chromosome-scale diploid unphased assembly of horsemint (Mentha longifolia). · BMC genomic data
7.PMID: 25429992 (2015) — Two antigenotoxic chalcone glycosides from Mentha longifolia subsp. longifolia. · Pharmaceutical biology
8.PMID: 25284948 (2013) — Pharmacological and therapeutic effects of Mentha Longifolia L. and its main constituent, menthol. · Ancient science of life
9.PMID: 37848594 (2023) — Efficient green silver nanoparticles-antibiotic combinations against antibiotic-resistant bacteria. · AMB Express
10.PMID: 36630114 (2023) — Anti-inflammatory and collagenation effects of zinc oxide-based nanocomposites biosynthesised with Mentha longifolia leaf extract. · Journal of wound care
11.PMID: 32525777 (2021) — Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review. · Current drug discovery technologies
12.PMID: 27867107 (2017) — Draft Genome Sequence of Mentha longifolia and Development of Resources for Mint Cultivar Improvement. · Molecular plant
13.PMID: 40255688 (2025) — Antibiofilm potential of plant extracts: inhibiting oral microorganisms and Streptococcus mutans. · Frontiers in dental medicine
14.PMID: 35551385 (2022) — Chromosome-level genome assembly of Mentha longifolia L. reveals gene organization underlying disease resistance and essential oil traits. · G3 (Bethesda, Md.)
15.PMID: 39775662 (2024) — Nutritional Profiling of Wild Edible Plants: Quantification of Macronutrients and Minerals via Energy Dispersive X-ray (EDX) Fluorescence Spectroscopy. · Brazilian journal of biology = Revista brasleira de biologia
16.PMID: 37123862 (2023) — Biochemical basis for the formation of organ-specific volatile blends in mint. · Frontiers in plant science
17.PMID: 34981485 (2021) — Role of Herbal Medicines in the Management of Brain Injury. · Advances in experimental medicine and biology
18.PMID: 32116670 (2019) — Anticancer Effects of Wild Mountain Mentha longifolia Extract in Adrenocortical Tumor Cell Models. · Frontiers in pharmacology
19.PMID: 34716886 (2021) — Mentha longifolia Alleviates Exogenous Serotonin-Induced Diabetic Hypoglycemia and Relieves Renal Toxicity via ROS Regulation. · Plant foods for human nutrition (Dordrecht, Netherlands)
20.PMID: 38985793 (2024) — Mentha longifolia assisted nanostructures: An approach to obliterate microbial biofilms. · PloS one
21.PMID: 41456269 (2025) — Modulatory effects of Mentha longifolia and Mentha spicata essential oils on Candida albicans biofilm formation. · Cellular and molecular biology (Noisy-le-Grand, France)
22.PMID: 31330767 (2019) — Antihypertensive Indigenous Lebanese Plants: Ethnopharmacology and a Clinical Trial. · Biomolecules
23.PMID: 39580133 (2025) — Kurdish ethnomedicine in the context of historic migration. · Journal of ethnopharmacology
24.PMID: 35270144 (2022) — Dynamic Tissue-Specific Transcriptome Changes in Response to Verticillium dahliae in Wild Mint Species Mentha longifolia. · Plants (Basel, Switzerland)
25.PMID: 42336988 (2026) — Preparation of enriched extracts from Mentha longifolia subsp. typhoides samples collected from different localities in terms of ursolic and oleanolic acids. · Scientific reports
26.PMID: 31353642 (2019) — Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load. · Journal of food biochemistry
27.PMID: 35846999 (2022) — Antidepressant Effects of South African Plants: An Appraisal of Ethnobotanical Surveys, Ethnopharmacological and Phytochemical Studies. · Frontiers in pharmacology
28.PMID: 34834841 (2021) — Chemotypes and Their Stability in Mentha longifolia (L.) L.-A Comprehensive Study of Five Accessions. · Plants (Basel, Switzerland)
29.PMID: 36375535 (2023) — Essential oils of four wild plants inhibit the blood seeking behaviour of female Aedes aegytpi. · Experimental parasitology