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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 25 PubMed articles · model: gemma4:31b
Summary
Menyanthes trifoliata (buckbean) is a medicinal aquatic plant found in Asia, Europe, and North America with documented anti-inflammatory, antioxidant, and cytotoxic properties [PMID:30610508, 31737178].
Background
Menyanthes trifoliata, also known as buckbean or bogbean, is an emergent aquatic plant that grows on peat bogs and swamps in Europe, North America, and Asia [PMID:31737178, 35050061].
Traditional uses
It has been used in traditional medicine for centuries as a remedy for anemia, lack of appetite [PMID:30610508], and in Swedish traditional medicine for the treatment of inflammatory kidney diseases such as glomerulonephritis [PMID:23196151]. In China, it is used as a hypnotic remedy in ethnomedicines [PMID:39647592].
Active compounds
The plant contains lupane triterpenoids (including 23-O-trans-feruloylcylicodiscic acid) [PMID:29658298], polyphenolic compounds such as sinapinic, ferulic, syringic, and vanilic acids [PMID:30610508], and secoiridoids including dihydrofoliamenthin, menthiafolin, and loganin [PMID:17262264]. It also contains immunomodulating polysaccharide fractions [PMID:15813366] and iridoids [PMID:19615800].
Mechanism of action
The herb may exert anti-inflammatory effects through the inhibition of platelet activating factor (PAF)-induced exocytosis and the inhibition of elastase activity [PMID:23195814, 23196151]. Certain extracts demonstrate the ability to induce apoptosis in grade IV glioma cells [PMID:30610508] and influence the expression of antioxidant (e.g., HO-1, NRF2) and inflammation-related genes (e.g., IL-6, TNF-α) [PMID:31737178].
Clinical evidence
Evidence DInflammation/Edema
Rhizome decoction inhibited carrageenan-induced rat paw edema and ethyl phenylpropiolate-induced rat ear edema in a dose-dependent manner [PMID:23196151].
Evidence DAcute Renal Failure
Oral administration of water decoction from rhizomes preserved renal function (higher GFR) after renal ischemia in rats [PMID:23195814].
Evidence DCancer (Glioma)
Root extracts exhibited cytotoxic effects and induced apoptosis in grade IV glioma cells in vitro, without affecting normal human astrocytes [PMID:30610508].
Evidence DInsomnia
Evaluated as a sedative-hypnotic candidate in mice using EEG/EMG and behavioral tests [PMID:39647592].
Safety & adverse effects
In a metallomic profiling study, compendial permissible limits for elements were not exceeded, and no evidence of non-carcinogenic risk was found [PMID:36266322]. A rhizome decoction showed only minor hemolytic activity [PMID:23196151].
Drug interactions
Bogbean is listed as a herbal product that may potentially increase the risk of bleeding or potentiate the effects of warfarin therapy [PMID:10902065].
Evidence summary
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating potential anti-inflammatory, anti-cancer, and sedative activities; there are no human clinical trials provided in the source material.
PubMed sources
1.PMID: 29658298 (2019) — Anti-inflammatory lupane triterpenoids from Menyanthes trifoliata. · Journal of Asian natural products research
2.PMID: 10902065 (2000) — Potential interactions between alternative therapies and warfarin. · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
3.PMID: 35050061 (2022) — Diurnal Change of the Photosynthetic Light-Response Curve of Buckbean (Menyanthes trifoliata), an Emergent Aquatic Plant. · Plants (Basel, Switzerland)
4.PMID: 36751911 (2023) — Plant phenology and species-specific traits control plant CH4 emissions in a northern boreal fen. · The New phytologist
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— Antioxidant Activity and Profile of Phenolic Compounds in Selected Herbal Plants.
· Plant foods for human nutrition (Dordrecht, Netherlands)
6.PMID: 30610508 (2019) — Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells. · Cytotechnology
7.PMID: 15813366 (2004) — Immunomodulating polysaccharide fractions of Menyanthes trifoliata L. · Zeitschrift fur Naturforschung. C, Journal of biosciences
8.PMID: 36833486 (2023) — The Influence of Shallow Peatland Water Quality on Characteristics of the Occurrence of Selected Herb Species in the Peatlands of Eastern Poland. · International journal of environmental research and public health
9.PMID: 39647592 (2025) — Evaluation of the sedative-hypnotic effects of Menyanthes trifoliata L. extract in mice. · Journal of ethnopharmacology
10.PMID: 36266322 (2022) — Novel metallomic profiling and non-carcinogenic risk assessment of botanical ingredients for use in herbal, phytopharmaceutical and dietary products using HR-ICP-SFMS. · Scientific reports
11.PMID: 31737178 (2019) — An Evaluation of the DNA-Protective Effects of Extracts from Menyanthes trifoliata L. Plants Derived from In Vitro Culture Associated with Redox Balance and Other Biological Activities. · Oxidative medicine and cellular longevity
12.PMID: 23195814 (1994) — The effect of Menyanthes trifoliata L. on acute renal failure might be due to PAF-inhibition. · Phytomedicine : international journal of phytotherapy and phytopharmacology
13.PMID: 21622434 (2010) — Development and multiplexing of microsatellite markers in the polyploid perennial herb, Menyanthes trifoliata (Menyanthaceae). · American journal of botany
14.PMID: 23196151 (1995) — Anti-inflammatory studies on Menyanthes trifoliata related to the effect shown against renal failure in rats. · Phytomedicine : international journal of phytotherapy and phytopharmacology
15.PMID: 19615800 (2009) — Effect of the temperature and the exclusion of UVB radiation on the phenolics and iridoids in Menyanthes trifoliata L. leaves in the subarctic. · Environmental pollution (Barking, Essex : 1987)
16.PMID: 12230887 (2002) — Selective cytotoxicity evaluation in anticancer drug screening of fractionated plant extracts. · Journal of biomolecular screening
17.PMID: 17262264 (1989) — [Further investigations regarding distribution and structure of the bitter principles from Menyanthes trifoliata]. · Planta medica
18.PMID: 33373786 (2021) — Process-based modeling to assess the nutrient removal efficiency of two endangered hydrophytes: Linking nutrient-cycle with a multiple-quotas approach. · The Science of the total environment
19.PMID: 41300392 (2025) — Vegetation and Landscape Shift After Beaver Settlement in a Mountainous Area. · Biology
20.PMID: 40885875 (2025) — Integrated profiling of essential metals, phenolic compounds, anti-inflammatory and hydroxyl radical scavenging activities for five medicinal plants. · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
21.PMID: 33385841 (2021) — Biogeochemistry of macrophytes, sediments and porewaters in thermokarst lakes of permafrost peatlands, western Siberia. · The Science of the total environment
22.PMID: 19889484 (2010) — The distribution of (137)Cs, K, Rb and Cs in plants in a Sphagnum-dominated peatland in eastern central Sweden. · Journal of environmental radioactivity