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PubMed · Tagetes lucida Cav. essential oil and the mixture of its main compounds are antibacterial and modulate antibiotic resistance in multi-resistant pathogenic bacteria. (2022)
PubMed · Tagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing properties. (2016)
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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Tagetes lucida, also known as Mexican marigold, yauhtli, or pericón, is a medicinal plant native to America used primarily in traditional Mexican medicine for central nervous system and inflammatory disorders [PMID:30388858, 32961278, 36365258].
Background
Tagetes lucida (Mexican marigold) is a species of the Tagetes genus native to America [PMID:30388858]. It is widely utilized in folk medicine, particularly in Mexico, to treat various health problems including those related to the central nervous system, inflammation, and gastrointestinal issues [PMID:30388858, 34789033, 36365258].
Traditional uses
In traditional Mexican medicine, it is used to treat anxiety, depressant diseases, pain, hypertension, and disorders associated with inflammation [PMID:32961278, 34789033]. It is also used as a remedy for gastrointestinal disorders causing stomachaches, abdominal cramps, and diarrhea [PMID:33193797].
Active compounds
Bioactive compounds include coumarins (such as herniarin, scoparone, dimethylfraxetin, 7-O-prenylscopoletin, 7-O-prenylumbelliferone, and umbelliferone) [PMID:30618303, 36365258, 33193797], flavonoids (quercetagetin, quercetin, and rutin) [PMID:19127719, 34789033], terpenes (including $\beta$-caryophyllene) [PMID:32033302], and essential oil components such as estragole, methyl eugenol, linalool, and geraniol [PMID:35419861, 35807645]. It also contains thiophenes, specifically 5-(3-buten-1-ynyl)-2,2'-bithienyl [PMID:20394003], and phenolic acids like gallic, chlorogenic, quinic, and shikimic acids [PMID:37446829].
Mechanism of action
Antidepressant-like effects are mediated by 5-HT(1A) and 5-HT(2A) receptors [PMID:26062718]. Some constituents act as monoamine oxidase A (MAO-A) inhibitors [PMID:37446829]. Antihypertensive effects involve vasorelaxant activity on aortic rings [PMID:32961278]. Antispasmodic activity has been observed in guinea pig ileum segments [PMID:33193797].
Clinical evidence
Evidence DDepression
Aqueous extracts showed antidepressant-like effects in rat forced swimming tests, reducing immobility and increasing swimming [PMID:18782612, 22809029, 26062718].
Evidence DInflammation/Pain
Coumarins and aqueous extracts demonstrated anti-inflammatory and antinociceptive effects in mice and rat models of auricular oedema and gout-pain [PMID:30618303, 34789033, 41067319].
Evidence DHypertension
Ethanolic extract lowered systolic and diastolic blood pressure in SHR rats without modifying heart rate [PMID:32961278].
Evidence DGastrointestinal Disorders
Aqueous extract showed antispasmodic activity in guinea pig ileum and antidiarrheal activity in the charcoal meal test in mice [PMID:33193797].
Evidence DBacterial Infection
Essential oil and its main compounds exhibited antibacterial activity and modulated antibiotic resistance in S. aureus and P. aeruginosa [PMID:35419861].
Evidence D
Safety & adverse effects
Acute toxicity of the aqueous extract was evaluated using OECD guideline 425 in mice [PMID:41067319]. No specific adverse effects were reported in the provided abstracts, though one study noted no adverse effects on male sexual behavior in rats [PMID:18782612].
Drug interactions
Extracts and isolated coumarins (herniarin and dimethylfraxetin) from T. lucida were found to increase the cataleptic effect of haloperidol in mice [PMID:36297813].
Evidence summary
The evidence is primarily based on in vitro studies and animal models (Level D), demonstrating potential antidepressant, anti-inflammatory, antihypertensive, and antibacterial properties. No human clinical trials were provided in the abstracts.
PubMed sources
1.PMID: 30388858 (2018) — Tagetes spp. Essential Oils and Other Extracts: Chemical Characterization and Biological Activity. · Molecules (Basel, Switzerland)
2.PMID: 34789033 (2022) — Isolation, chemical characterization, and anti-inflammatory activity of coumarins, flavonoids, and terpenes from Tagetes lucida. · Natural product research
3.PMID: 36297813 (2022) — Herniarin, Dimethylfraxetin and Extracts from Tagetes lucida, in Psychosis Secondary to Ketamine and Its Interaction with Haloperidol. · Plants (Basel, Switzerland)
4.PMID: 32961278 (2021) — Antihypertensive and vasorelaxant mode of action of the ethanol-soluble extract from Tagetes lucida Cav. aerial parts and its main bioactive metabolites. · Journal of ethnopharmacology
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Root ethanol extract showed hepatoprotective effects in CCl4-induced hepatotoxicity in rats by ameliorating oxidative stress [PMID:34347571].
(2020)
— Anti-inflammatory activity of coumarins isolated from Tagetes lucida Cav.
· Natural product research
6.PMID: 26062718 (2015) — Antidepressant-like activity of Tagetes lucida Cav. is mediated by 5-HT(1A) and 5-HT(2A) receptors. · Journal of natural medicines
7.PMID: 36365258 (2022) — Pharmacokinetics and Tissue Distribution of Coumarins from Tagetes lucida in an LPS-Induced Neuroinflammation Model. · Plants (Basel, Switzerland)
8.PMID: 32033302 (2020) — Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil. · Molecules (Basel, Switzerland)
9.PMID: 35419861 (2022) — Tagetes lucida Cav. essential oil and the mixture of its main compounds are antibacterial and modulate antibiotic resistance in multi-resistant pathogenic bacteria. · Letters in applied microbiology
10.PMID: 41067319 (2026) — Antinociceptive effect of Tagetes lucida in an arthritic gout-pain model in rats. · Journal of ethnopharmacology
11.PMID: 22809029 (2012) — Antidepressant-like effect of Tagetes lucida Cav. extract in rats: involvement of the serotonergic system. · The American journal of Chinese medicine
12.PMID: 19127719 (2006) — Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida). · Journal of agricultural and food chemistry
13.PMID: 33193797 (2020) — Study of Antispasmodic and Antidiarrheal Activities of Tagetes lucida (Mexican Tarragon) in Experimental Models and Its Mechanism of Action. · Evidence-based complementary and alternative medicine : eCAM
14.PMID: 37446829 (2023) — Analysis of Antioxidant Constituents of Filtering Infusions from Oak (Quercus sideroxyla Bonpl. and Quercus eduardii Trel.) and Yerbaniz (Tagetes lucida (Sweet) Voss) as Monoamine Oxidase Inhibitors. · Molecules (Basel, Switzerland)
15.PMID: 18782612 (2008) — Antidepressant-like effects of Tagetes lucida Cav. in the forced swimming test. · Journal of ethnopharmacology
16.PMID: 34347571 (2021) — Hepatoprotective effects of Tagetes lucida root extract in carbon tetrachloride-induced hepatotoxicity in Wistar albino rats through amelioration of oxidative stress. · Pharmaceutical biology
17.PMID: 35807645 (2022) — Photoprotective Agents Obtained from Aromatic Plants Grown in Colombia: Total Phenolic Content, Antioxidant Activity, and Assessment of Cytotoxic Potential in Cancer Cell Lines of Cymbopogon flexuosus L. and Tagetes lucida Cav. Essential Oils. · Plants (Basel, Switzerland)
18.PMID: 20394003 (2010) — Thiophene occurrence in different Tagetes species: agricultural biomasses as sources of biocidal substances. · Journal of the science of food and agriculture