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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Michelia champaca is a perennial tree of the Magnoliaceae family known for its aromatic flowers and diverse pharmacological properties, including antioxidant, antimicrobial, and anticancer activities [PMID:36364127, 12490248, 38496875].
Background
Michelia champaca (also referred to as Magnolia champaca) is an ornamentally important perennial tree in the Magnoliaceae family [PMID:33457969, 36364127]. It is cultivated for its highly fragrant flowers, which are used as cosmetic raw materials and in the flavors and fragrances industry [PMID:38471573, 28615048].
Traditional uses
In the Chhattisgarh state of India, the plant is traditionally used by Bhatra women for fertility regulation [PMID:23501154]. It is also noted for general aromatic, ethnobotanical, and medicinal uses [PMID:36364127].
Active compounds
The plant contains a variety of bioactive compounds: sesquiterpene lactones such as micheliolide, parthenolide, and costunolide [PMID:38496875, 889597]; phenylethanoid glycosides (PhGs) and flavonoid glycosides (including champaflavosides A-D) in the leaves [PMID:38692344, 38471573]; alkaloids such as liriodenine, anonaine, asimilobine, and nuciferine [PMID:12490248, 21941890]; and volatile organic compounds including 1,8-cineole, methyl benzoate, and beta-elemene [PMID:22799101, 36364127].
Mechanism of action
Micheliolide (MCL) modulates several signaling cascades, including the inhibition of NF-κB and STAT3 pathways, and the activation of Nrf2, AMPK, and NLRP3 [PMID:38496875, 42065912, 39467351]. MCL induces apoptosis by arresting the cell cycle at G1/G0, S, and G2/M phases and activating the cytochrome c/caspase-dependent apoptotic pathway [PMID:38496875, 32863900].
Clinical evidence
Evidence DCancer (various cell lines)
Liriodenine showed strong inhibition of human breast and lung cancer cells [PMID:21941890]. Micheliolide (MCL) inhibited viability, migration, and invasion of human glioma U251MG cells [PMID:32863900] and exerted selective cytotoxic effects on CD34+CD38- leukemic stem cells [PMID:27542251].
Evidence DDiabetes
Ethanolic extract of flower buds exhibited significant antihyperglycemic and antidiabetic activity in glucose-overloaded and alloxan-induced diabetic rat models [PMID:21279181].
Evidence DNeuropsychiatric Disorders
Ethanol extract of leaves (EEMC) demonstrated antidepressant activity in forced swim and tail suspension tests, and anxiolytic activity in elevated plus maze and light/dark tests in mice [PMID:36052952].
Evidence DSevere Acute Pancreatitis (SAP)
Micheliolide treatment alleviated pancreatic injury (necrosis, edema, vacuolation) and reduced serum amylase and lipase levels in murine models via Nrf2 activation [PMID:39467351].
Evidence DBacterial/Fungal Infections
Methanol extracts of leaves, seeds, stem, and root barks exhibited broad-spectrum antibacterial activity; liriodenine was identified as an active constituent of the root bark [PMID:12490248].
Pregnancy & lactation
Traditionally used for fertility regulation by women in Chhattisgarh, India [PMID:23501154]. No safety data provided in the abstracts.
Evidence summary
The current evidence is primarily based on in vitro assays and animal models (Level D), demonstrating significant potential for antioxidant, anticancer, and antidiabetic activities, particularly through the compound micheliolide.
4.PMID: 33457969 (2020) — Complete chloroplast genome sequence of Michelia champaca var. champaca Linnaeus, an ornamental tree species of Magnoliaceae. · Mitochondrial DNA. Part B, Resources
5.PMID: 38454977 (2023) — Antioxidant and antiaging activities of Cinnamomum burmannii, Michelia champaca and their combinations. · Narra J
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Extract administration significantly increased superoxide dismutase (SOD) levels and regulated apoptotic-related proteins (Bax and Bcl-2) in the hippocampus of middle-aged female rats [PMID:39006048].
Evidence DInflammation
Methanolic flower extracts showed antiinflammatory activity against cotton pellet granuloma in rats [PMID:9567766].
6.PMID: 36364127 (2022) — Volatile Profiling of Magnolia champaca Accessions by Gas Chromatography Mass Spectrometry Coupled with Chemometrics. · Molecules (Basel, Switzerland)
7.PMID: 37700379 (2023) — Octadecadienoate derivatives from Michelia champaca seed extract as potential larvicide and pupicide against Dengue vector Aedes albopictus. · BMC research notes
8.PMID: 36052952 (2022) — New insights on the phytochemical intervention for the treatment of neuropsychiatric disorders using the leaves of Michelia champaca: an in vivo and in silico approach. · Pharmaceutical biology
10.PMID: 39006048 (2024) — Michelia Champaca L. Modulates Superoxide Dismutase and Apoptosis-Regulating Proteins in Hippocampus of Middle-Aged Female Rats. · Journal of microscopy and ultrastructure
11.PMID: 21279181 (2008) — Antidiabetic activity of flower buds of Michelia champaca Linn. · Indian journal of pharmacology
12.PMID: 37998755 (2023) — Phylogenetics Study to Compare Chloroplast Genomes in Four Magnoliaceae Species. · Current issues in molecular biology
13.PMID: 38496875 (2024) — Pharmacological potential of micheliolide: A focus on anti-inflammatory and anticancer activities. · Heliyon
14.PMID: 28615048 (2017) — Integrated metabolome and transcriptome analysis of Magnolia champaca identifies biosynthetic pathways for floral volatile organic compounds. · BMC genomics
16.PMID: 23501154 (2013) — Antifertility effect of hydroalcoholic leaves extract of Michelia champaca L.: an ethnomedicine used by Bhatra women in Chhattisgarh state of India. · Journal of ethnopharmacology
17.PMID: 14154268 (1964) — LIRIODENINE FROM MICHELIA CHAMPACA. · Bulletin of the Calcutta School of Tropical Medicine
18.PMID: 25421415 (2014) — Antifungal compounds produced by Colletotrichum gloeosporioides, an endophytic fungus from Michelia champaca. · Molecules (Basel, Switzerland)
19.PMID: 889597 (1977) — Cytotoxic agents from Michelia champaca and Talauma ovata: parthenolide and costunolide. · Journal of pharmaceutical sciences
20.PMID: 19473794 (2009) — In vitro screening for anthelmintic and antitumour activity of ethnomedicinal plants from Thailand. · Journal of ethnopharmacology
21.PMID: 22799101 (2012) — Volatiles from Michelia champaca flower: comparative analysis by simultaneous distillation-extraction and solid phase microextraction. · Natural product communications
22.PMID: 6505094 (1984) — Constituents of Michelia champaca and Lewis acid catalysed transformations of parthenolide into guaianolides. · Planta medica
23.PMID: 39467351 (2024) — Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects. · International immunopharmacology
24.PMID: 32863900 (2020) — Micheliolide suppresses the viability, migration and invasion of U251MG cells via the NF-κB signaling pathway. · Oncology letters
25.PMID: 27542251 (2016) — Antineoplastic effects and mechanisms of micheliolide in acute myelogenous leukemia stem cells. · Oncotarget
26.PMID: 9567766 (1997) — Antiinflammatory and antipyretic activity of Michelia champaca Linn., (white variety), Ixora brachiata Roxb. and Rhynchosia cana (Willd.) D.C. flower extract. · Indian journal of experimental biology
27.PMID: 42065912 (2026) — Therapeutic Potential of Micheliolide and ACT001 in Age-Related Diseases: Molecular Mechanisms and Clinical Prospects. · Aging and disease
28.PMID: 14002453 (1963) — [Studies on the alkaloids of magnoliaceous plants. 36, Alkaloids of Michelia champaca Linn]. · Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
29.PMID: 15187448 (2004) — In vitro screening of leishmanicidal activity in myanmar timber extracts. · Biological & pharmaceutical bulletin