PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Oligosaccharides mitigated depression-like behaviors in hypertension rats [PMID:36765376] and monotropein exerted antidepressant effects in LPS-induced mouse models [PMID:42150287].
Polysaccharides (MOPs) attenuated osteoporosis in ovariectomized rats by suppressing the PGC-1α/PPARγ pathway [PMID:36369661] and regulating miR-214-3p/NEDD4L [PMID:39198270].
Oligosaccharides ameliorated memory in APP/PS1 transgenic mice by improving gut microbiota [PMID:29962999].
Oligosaccharides improved sperm motility and quality in gossypol-induced asthenozoospermia mouse models [PMID:41561043].
The anthraquinone M13 alleviated progression of osteoarthritis via regulation of STAT3 [PMID:39706062], and nystose mitigated knee osteoarthritis by inhibiting the NLRP3 inflammasome [PMID:41338111].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 36765376 (2023) — Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy. · Journal of neuroinflammation
- 2.PMID: 38663117 (2024) — Morinda Officinalis-derived extracellular vesicle-like particles: Anti-osteoporosis effect by regulating MAPK signaling pathway. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 3.PMID: 40377182 (2025) — Morinda Officinalis-Derived Extracellular Vesicle-like Particles Promote Wound Healing via Angiogenesis. · ACS applied materials & interfaces
- 4.PMID: 21582815 (2009) — 3-Hydr-oxy-1,2-dimethoxy-anthraquinone. · Acta crystallographica. Section E, Structure reports online
- 5.PMID: 40450983