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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Common mullein (Verbascum thapsus L.) is a medicinal plant used traditionally for pulmonary, inflammatory, and wound-related conditions [PMID:16222647, PMID:35088467].
Background
Verbascum thapsus L., also known as great mullein or common mullein, is a biennial plant indigenous to Europe, northern Africa, and western and central Asia, and has been introduced to the Americas and Australia [PMID:35088467, PMID:37009556].
Traditional uses
It has been used to treat pulmonary problems, inflammatory diseases, asthma, spasmodic coughs, diarrhoea, migraine headaches [PMID:16222647], lung, skin, and throat disorders [PMID:35088467], and as an antispasmodic, anti-tubercular agent, and wormicide in tribal medicine [PMID:22463730]. Root extracts have been used for toothache, stiffness, and seizures [PMID:35088467], while other traditional uses include treating genitourinary infections [PMID:26239850] and whooping cough [PMID:39183880].
Active compounds
Phytoconstituents include flavonoids, saponins, tannins, terpenoids, glycosides (iridoid, phenylethanoid, and phenylpropanoid), coumarin, hesperidin, and vitamin C [PMID:35088467, PMID:22463730]. Specific identified compounds include p-coumaric acid, ferulic acid, rutin [PMID:36297503], and acteoside [PMID:40549319].
Mechanism of action
Traditional uses may rely on the anti-inflammatory action of phytochemicals such as quercetin [PMID:34356473]. In vitro studies suggest the plant may induce apoptosis in Trichomonas vaginalis [PMID:26239850] and exhibit antioxidant activity via DPPH and ABTS radical scavenging [PMID:38279434, PMID:31456524].
Clinical evidence
Evidence BEpisiotomy wound healing
A randomized, double-blind, controlled clinical trial evaluated the effect of Verbascum Thapsus on episiotomy wound healing in primiparous women [PMID:34103042].
Safety & adverse effects
Toxicity to brine shrimp and radish seed germination was observed at higher concentrations of extracts [PMID:12241986].
Evidence summary
The evidence consists primarily of in vitro studies, animal/plant bioassays, and reviews of traditional use, with one randomized controlled trial regarding wound healing. Overall clinical evidence in humans is limited.
PubMed sources
1.PMID: 16222647 (2005) — Common mullein (Verbascum thapsus L.): recent advances in research. · Phytotherapy research : PTR
2.PMID: 35088467 (2022) — Health-promoting and disease-mitigating potential of Verbascum thapsus L. (common mullein): A review. · Phytotherapy research : PTR
3.PMID: 22463730 (2012) — Anthelmintic and relaxant activities of Verbascum Thapsus Mullein. · BMC complementary and alternative medicine
4.PMID: 36297503 (2022) — Gold Nanoparticles Synthesized with Common Mullein (Verbascum thapsus) and Castor Bean (Ricinus communis) Ethanolic Extracts Displayed Antiproliferative Effects and Induced Caspase 3 Activity in Human HT29 and SW480 Cancer Cells. · Pharmaceutics
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
— The Antioxidant, Anticarcinogenic and Antimicrobial Properties of Verbascum thapsus L.
· Medicinal chemistry (Shariqah (United Arab Emirates))
6.PMID: 12241986 (2002) — Biological activity of common mullein, a medicinal plant. · Journal of ethnopharmacology
7.PMID: 36082042 (2022) — The complete chloroplast genome of Verbascum thapsus L. (Scrophulariaceae) and its phylogenetic affinities. · Mitochondrial DNA. Part B, Resources
8.PMID: 37009556 (2023) — The Complete Genome Sequence of Verbascum thapsus (Scrophulariaceae, Lamiales), the Common Mullein. · Biodiversity genomes
9.PMID: 34356473 (2021) — Searching for Scientific Explanations for the Uses of Spanish Folk Medicine: A Review on the Case of Mullein (Verbascum, Scrophulariaceae). · Biology
10.PMID: 26239850 (2015) — Effect of Verbascum thapsus ethanol extract on induction of apoptosis in Trichomonas vaginalis in vitro. · Infectious disorders drug targets
11.PMID: 38279434 (2023) — Antioxidant, AChE inhibitory, and anticancer effects of Verbascum thapsus extract. · Cellular and molecular biology (Noisy-le-Grand, France)
12.PMID: 34103042 (2021) — The effect of the Verbascum Thapsus on episiotomy wound healing in nulliparous women: a randomized controlled trial. · BMC complementary medicine and therapies
13.PMID: 39183880 (2024) — Bioassay-guided fractionation of Verbascum thapsus extract and its combination with polyvinyl alcohol in the form electrospun nanofibrous membrane for efficient wound dressing application. · Heliyon
14.PMID: 40549319 (2025) — Acteoside as a multifunctional natural glycoside: therapeutic potential across various diseases. · Inflammopharmacology