PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Aqueous and organic extracts, as well as essential oil and Z-ligustilide, exhibited significant antinociceptive effects in mouse models of thermal and chemical pain [PMID:24093628]
Root extracts and (Z)-3-butylidenephthalide showed significant hypoglycemic and antihyperglycemic effects in diabetic mice [PMID:20879744]
Organic extracts and diligustilide demonstrated gastroprotective activity by inhibiting ethanol-induced lesions in rats [PMID:26320689]
Root extract increased the viability of human peripheral blood lymphocytes and reduced lipid peroxidation in H2O2-stressed cells [PMID:27854198, PMID:28539739]
Ethanolic root extract and isolated butylidenephthalides showed significant repellency against Aedes aegypti mosquitoes and imported fire ants [PMID:39255862, PMID:39590427]
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 28539739 (2017) — Effects of Ligusticum porteri (Osha) Root Extract on Human Promyelocytic Leukemia Cells. · Pharmacognosy research
- 2.PMID: 39255862 (2024) — Bioassay-guided isolation of insect repellent compounds from Ligusticum porteri root extract. · Acta tropica
- 3.PMID: 38362356 (2023) — ANALYSIS OF SOUTHWESTERN COLORADO LIGUSTICUM PORTERI BY GAS CHROMATOGRAPHY - MASS SPECTROMETRY. · Journal of undergraduate chemistry research
- 4.PMID: 24093628 (2014) — Antinociceptive activity of Ligusticum porteri preparations and compounds. · Pharmaceutical biology
- 5.PMID: 27854198 (2016) — Investigation of the cytotoxicity, antioxidative and immune-modulatory effects of Ligusticum porteri (Osha) root extract on human peripheral blood lymphocytes.