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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Oxalis corniculata is a globally distributed medicinal herb known for its antioxidant, anti-inflammatory, and antimicrobial properties [PMID:34391377, 41300509, 41240331].
Background
Oxalis corniculata (Oxalidaceae), also known as creeping wood sorrel or Indian sorrel, is a small, delicate, perennial herb found in warm temperate and tropical regions, including India and Pakistan [PMID:34391377, 33889744, 37544341, 41240331]. It has a worldwide distribution and archaeobotanical evidence places its presence in south-east Asia at least 5,000 years ago [PMID:30783568].
Traditional uses
Traditionally used as food and in the management of epilepsy, gastric disorders, neurodegenerative diseases, bacterial infections, and kidney stones [PMID:38218505, 30039767]. It is also incorporated into approved Chinese patent medicines [PMID:41300509].
Active compounds
Bioactive constituents include flavonoids, alkaloids, terpenoids, cardiac glycosides, saponins, phlobatannins, steroids, phenolic acids, tannins, and polysaccharides [PMID:34391377, 41300509, 37544341, 42105471, 41240331]. Specific identified compounds include diosmin, naringenin-7-O-glucuronide, chrysophanol 8-O-glucoside, and guanosine [PMID:37544341, 39213214, 42165052].
Mechanism of action
The herb exhibits antioxidant-driven pharmacological effects [PMID:41300509]. In prostate cancer PC-3 cells, it inhibits proliferation and induces apoptosis by upregulating IκBα and downregulating p-p65 and p-IκBα in the NF-κB pathway [PMID:38597700]. In fracture healing, active components target proteins such as GAPDH, TNF, and TP53 [PMID:42165052]. It also inhibits α-glucosidase and α-amylase enzymes [PMID:41752406].
Clinical evidence
Evidence DAlzheimer's disease (rat model)
Methanolic extract showed neuroprotective effects against AlCl3-induced AD [PMID:38218505]
Evidence DHepatotoxicity (rat model)
Ethanolic extract significantly reduced malondialdehyde levels and serum enzymes in paracetamol-induced liver damage [PMID:24597147]
Warm water decoction was explored for its mechanism against the condition [PMID:38639589]
Safety & adverse effects
Its use in traditional remedies and approved Chinese patent medicines underscores its safety [PMID:41300509].
Evidence summary
The current evidence is primarily based on in vitro studies, animal models, and literature reviews. There is a noted lack of clinical trials and effective pharmacological studies in humans [PMID:34391377].
PubMed sources
1.PMID: 34391377 (2022) — A Review on Phyto-pharmacology of Oxalis corniculata. · Combinatorial chemistry & high throughput screening
2.PMID: 35054508 (2022) — Metabolomic Profiles of the Creeping Wood Sorrel Oxalis corniculata in Radioactively Contaminated Fields in Fukushima: Dose-Dependent Changes in Key Metabolites. · Life (Basel, Switzerland)
3.PMID: 34575139 (2021) — Metabolomic Response of the Creeping Wood Sorrel Oxalis corniculata to Low-Dose Radiation Exposure from Fukushima's Contaminated Soil. · Life (Basel, Switzerland)
4.PMID: 41300509 (2025) — Oxalis corniculata L. As a Source of Natural Antioxidants: Phytochemistry, Bioactivities, and Application Potential. · Antioxidants (Basel, Switzerland)
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Ethyl acetate fraction showed potent inhibition of α-glucosidase and α-amylase [PMID:41752406]
(2018)
— Enhancer assisted-phytoremediation of mercury-contaminated soils by Oxalis corniculata L., and rhizosphere microorganism distribution of Oxalis corniculata L.
· Ecotoxicology and environmental safety
6.PMID: 30783568 (2019) — The origin of Oxalis corniculata L. · PeerJ
7.PMID: 33889744 (2021) — The complete chloroplast genome sequence of Oxalis corniculata (L.). · Mitochondrial DNA. Part B, Resources
8.PMID: 39213214 (2024) — Exploring the action mechanism of Oxalis corniculata L. decoction in treating osteoarthritis utilizing liquid chromatography-mass spectrometry technology combined with network pharmacology. · Medicine
9.PMID: 36698692 (2022) — Apoptosis Effects of Oxalis corniculata L. Extract on Human MCF-7 Breast Cancer Cell Line: · Galen medical journal
10.PMID: 38218505 (2024) — The potential anti-Alzheimer's activity of Oxalis corniculata Linn. Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-κβ/NLRP3, Wnt 3/β-catenin/GSK-3β, autophagy and apoptotic cues. · Journal of ethnopharmacology
11.PMID: 35579221 (2022) — An acidic polysaccharide from Oxalis corniculata L. and the preliminary study on its antioxidant activity. · Journal of food biochemistry
12.PMID: 37544341 (2024) — Diosmin: A Daboia russelii venom PLA2s inhibitor- purified, and characterized from Oxalis corniculata L medicinal plant. · Journal of ethnopharmacology
13.PMID: 34054321 (2021) — Hybridization of Oxalis corniculata and O. dillenii in their non-native range. · PhytoKeys
14.PMID: 32717796 (2020) — Complete Chloroplast Genome Characterization of Oxalis Corniculata and Its Comparison with Related Species from Family Oxalidaceae. · Plants (Basel, Switzerland)
15.PMID: 38639589 (2023) — [Research on the mechanism of Miao ethnicity medicine formula of Oxalis corniculata against chronic non-bacterial prostatitis]. · Zhonghua nan ke xue = National journal of andrology
16.PMID: 38597700 (2023) — [Biological mechanisms of Oxalis corniculata regulating human prostate cancer PC-3 cells: An investigation based on the NF-κB pathway]. · Zhonghua nan ke xue = National journal of andrology
17.PMID: 30039767 (2018) — Antibacterial and In Vitro Growth Inhibition Study of Struvite Urinary Stones Using Oxalis corniculata Linn. Leaf Extract and its Biofabricated Silver Nanoparticles. · Recent patents on drug delivery & formulation
18.PMID: 42105471 (2026) — "Multiscale computational analysis guided discovery of a multitarget antitubercular ligand from Oxalis corniculata Linn.". · Computational biology and chemistry
20.PMID: 41752406 (2026) — Beyond α-Glucosidase and α-Amylase Inhibition: Integrated In Vitro and Multi-Scale In Silico Insights into the Antidiabetic and Antioxidant Mechanisms of Oxalis corniculata L. Aerial Parts. · Molecules (Basel, Switzerland)
21.PMID: 24597147 (2014) — Hepatoprotective activity of Oxalis corniculata L. ethanolic extract against paracetamol induced hepatotoxicity in Wistar rats and its in vitro antioxidant effects. · Indian journal of experimental biology
22.PMID: 25873973 (2015) — Antibacterial, Antifungal, and Insecticidal Potentials of Oxalis corniculata and Its Isolated Compounds. · International journal of analytical chemistry
23.PMID: 23796759 (2015) — Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata. · Toxicology and industrial health
24.PMID: 37862418 (2023) — From green to red: Urban heat stress drives leaf color evolution. · Science advances
25.PMID: 39853493 (2025) — Phytochemicals that Regulate Oviposition Mistakes of Eurema mandarina on Oxalis corniculata. · Journal of chemical ecology
26.PMID: 39045239 (2024) — Isolation of bioactive compounds from low-cost agricultural resources and its utilization in daily life. · Access microbiology
27.PMID: 41240331 (2026) — Chemical Diversity and Biomedical Relevance of Oxalis corniculata L.: A Review of Nutritional and Pharmacological Aspects. · Chemistry & biodiversity