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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Paeonia veitchii is a medicinal herb from the Qinghai-Tibet Plateau used in traditional Chinese medicine, primarily as a source of red peony root (Paeoniae Radix Rubra) [PMID:36698081, PMID:38850115].
Background
Paeonia veitchii Lynch is a well-known herb from the Qinghai-Tibet Plateau south of the Himalayas [PMID:36698081]. Its dried root is one of the botanical origins of the traditional Chinese medicine known as Paeoniae Radix Rubra (Chishao) [PMID:38114171, PMID:39329953, PMID:40946821].
Traditional uses
It is traditionally employed to clear heat, cool the blood, dispel blood stasis, and alleviate pain [PMID:38850115, PMID:39329953]. It is also commonly used to treat heart disease, menstrual irregularities, uterine fibroids, arthritis, and cough, though data supporting these specific uses is poor [PMID:30000962].
Active compounds
The roots contain monoterpene glycosides (including paeoniflorin, albiflorin, benzoylpaeoniflorin, and the new glycosides paeonidanin I, J, and K), polyphenols (such as 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose, gallic acid, and naringin), and paeonols (including paeonol and paeonoside) [PMID:22070681, PMID:27268664, PMID:30000962, PMID:33155408]. Other constituents include flavonoids, proanthocyanidins, tannins, terpenoids, triterpenoids, and complex polysaccharides [PMID:30000962].
Mechanism of action
Paeoniflorin may enhance tubular repair by promoting dihydroorotate dehydrogenase-dependent epithelial cell proliferation [PMID:41475629] and inhibit melanogenesis by regulating melanin-related signal transduction [PMID:37288793]. Albiflorin may alleviate liver injury by inactivating the P38MAPK/NF-κB signaling pathway [PMID:38381358]. The herb's polyphenols are described as neuroprotectants, antioxidants, anti-inflammatory, and antithrombic agents [PMID:22070681].
Clinical evidence
Evidence DHyperuricemia
Paeonia veitchii extract demonstrated a uric acid-lowering effect through inhibition of xanthine oxidase and regulation of renal urate transporters in mice and liver cells [PMID:38176275]
Evidence DVascular occlusive diseases
Paeoniae Radix Rubra (including P. veitchii) dose-dependently enhanced endothelial cell proliferation and migration, suggesting pro-angiogenic potential via ADAM10-NOTCH and VEGFR2-PI3K/AKT signaling [PMID:40946821]
Evidence CLiver Diseases
Paeoniflorin demonstrates hepatic protection, cholestasis alleviation, and liver fibrosis attenuation via multiple pathways including TLR4-NF-κB and PI3K/Akt/Nrf2 [PMID:32410996]
Safety & adverse effects
Paeonia is generally well tolerated, but can occasionally cause gastrointestinal upset and allergic skin reactions, particularly when applied topically [PMID:30000962].
Pregnancy & lactation
Paeony can lower serum prolactin, which might suppress lactation; therefore, it is probably best to avoid during breastfeeding [PMID:30000962]. No data exist on the safety and efficacy of peony in nursing mothers or infants [PMID:30000962].
Evidence summary
The evidence consists primarily of laboratory-based studies (cell cultures and animal models) and pharmacological reviews. There is a lack of high-level clinical trial data specifically for Paeonia veitchii, although some clinical data exists for the broader category of red peony root (Paeoniae Radix Rubra).
PubMed sources
1.PMID: 30000962 (2006) — A Pharmacological Review of Bioactive Constituents of Paeonia lactiflora Pallas and Paeonia veitchii Lynch. · Phytotherapy research : PTR
2.PMID: 27268664 (2017) — Monoterpene glycosides from Paeonia veitchii. · Journal of Asian natural products research
3.PMID: 36698081 (2023) — Illuminating the biosynthesis pathway genes involved in bioactive specific monoterpene glycosides in Paeonia veitchii Lynch by a combination of sequencing platforms. · BMC genomics
4.PMID: 22070681 (2011) — Polyphenols and neuroprotection against ischemia and neurodegeneration. · Mini reviews in medicinal chemistry
5.PMID: 38114171 (2023) — [Selection and validation of reference genes for quantitative real-time PCR analysis in Paeonia veitchii].
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
· Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
6.PMID: 30144752 (2018) — Advancement in the chemical analysis of Paeoniae Radix (Shaoyao). · Journal of pharmaceutical and biomedical analysis
7.PMID: 38133706 (2024) — Comprehensive study on genetic and chemical diversity of Asian medicinal plants, aimed at sustainable use and standardization of traditional crude drugs. · Journal of natural medicines
8.PMID: 32371143 (2020) — Total glucosides of paeony: A review of its phytochemistry, role in autoimmune diseases, and mechanisms of action. · Journal of ethnopharmacology
9.PMID: 40946821 (2026) — Network pharmacology and molecular docking reveal the multi-target mechanisms of Paeoniae Radix Rubra in functional angiogenesis: Synergistic regulation of ADAM10-NOTCH and VEGFR2-PI3K/AKT signaling. · Journal of ethnopharmacology
10.PMID: 39329953 (2024) — Progress in the Study of Chemical Structure and Pharmacological Effects of Total Paeony Glycosides Isolated from Radix Paeoniae Rubra. · Current issues in molecular biology
11.PMID: 33155408 (2020) — New Insights into the Impact of Ecological Factor on Bioactivities and Phytochemical Composition of Paeonia veitchii. · Chemistry & biodiversity
12.PMID: 32410996 (2020) — Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases-A Mini Review. · Frontiers in pharmacology
13.PMID: 38176275 (2024) — Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters. · Phytomedicine : international journal of phytotherapy and phytopharmacology
14.PMID: 38850115 (2024) — Paeoniae Radix Rubra: A Review of Ethnopharmacology, Phytochemistry, Pharmacological Activities, Therapeutic Mechanism for Blood Stasis Syndrome, and Quality Control. · Chemistry & biodiversity
15.PMID: 41475629 (2026) — Paeoniflorin enhances tubular repair by promoting dihydroorotate dehydrogenase-dependent epithelial cell proliferation in cisplatin-induced chronic kidney disease. · Journal of ethnopharmacology
16.PMID: 37288793 (2023) — Paeoniflorin found in Paeonia lactiflora root extract inhibits melanogenesis by regulating melanin-related signal transduction in B16F10 cells. · Journal of cosmetic dermatology
17.PMID: 38381358 (2024) — Albiflorin Alleviates Severe Acute Pancreatitis-Associated Liver Injury by Inactivating P38MAPK/NF-κB Signaling Pathway. · Biochemical genetics