PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Reduced prostate weight, proliferative index, and expression of AR, SRD5A1, and PSA in rat models [PMID:31873149]; inhibited viability and induced apoptosis in human BPH cells [PMID:32416730].
Suppressed growth and induced apoptosis in LNCaP cells and suppressed tumor growth by up to 80% in xenograft mice [PMID:19476740]; suppressed growth, survival, and invasion of castration-resistant PC3 cells [PMID:24287876].
Potentiated carboplatin effects against ovarian cancer in preclinical models [PMID:24033267] and inhibited ovarian cancer stem cells in vitro [PMID:36178054].
Induced apoptosis in pancreatic cancer cell lines and showed synergistic effects when combined with gemcitabine in vitro and in vivo [PMID:23674070, 29985062].
Flavopereirine lowered cellular viability and induced apoptosis and G2/M-phase cell cycle arrest in CRC cells [PMID:31336690].
Safety & adverse effects
Drug interactions
Evidence summary
PubMed sources
- 1.PMID: 35665643 (2022) — Characterization of alkaloids in bark extracts of Geissospermum vellosii by HPLC-UV-diode array-multistage high-resolution mass spectrometry. · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- 2.PMID: 31873149 (2019) — Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by inhibiting 5α-Reductase. · Scientific reports
- 3.PMID: 24033267 (2014) — The plant extract of Pao pereira potentiates carboplatin effects against ovarian cancer. · Pharmaceutical biology
- 4.PMID: 39113866 (2024) — Flavopereirine exerts anti-cancer activities in various human thyroid cancer cells. · American journal of cancer research
- 5.PMID: 19497357