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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Bergenia ciliata, commonly known as Pashanbheda, is a medicinal herb from the Saxifragaceae family used primarily for treating kidney stones and various other ailments [PMID:29102914, PMID:23256653].
Background
Bergenia ciliata (Haw.) Sternb. is a perennial medicinal plant predominantly found in the Indian Himalayan Region [PMID:38091581, PMID:32377047]. It belongs to the Saxifragaceae family and is used in traditional Chinese, Nepalese, and Indian medicine [PMID:23256653].
Traditional uses
It is traditionally used to treat kidney and bladder stones, cough, pulmonary diseases, gastrointestinal disorders, diabetes mellitus, rheumatism, wounds, burns, and dental disorders such as tooth decay and toothaches [PMID:29102914, PMID:23256653, PMID:16414865, PMID:30898582, PMID:39577678].
Active compounds
Active compounds include bergenin, norbergenin, catechin, gallic acid, arbutin, polyphenols, pyrogallol, rutin, morin, quercetin rhamnodiglucoside, quercetin-3-O-rutinoside, kaempferol, and palmatic acid [PMID:23256653, PMID:31694704, PMID:37654052].
Mechanism of action
Bergenin has demonstrated anti-Helicobacter pylori activity [PMID:30362366]. In silico studies suggest flavonoids like 3-O-galloylepicatechin may inhibit AChE and GSK-3β [PMID:41547327]. The extract IIIM-160 inhibits lipopolysaccharide-induced production of proinflammatory cytokines, specifically interleukin-6 (IL-6) [PMID:30898582].
Clinical evidence
Evidence CKidney Stones
Reported as a well-known treatment for kidney disorders, particularly kidney stones [PMID:29102914].
Evidence DWound Healing
Ethanolic extract of rhizome showed wound healing activity in Wistar rats [PMID:34411656].
Evidence DDiabetes (Hypoglycemic activity)
Extracts of root and leaves showed hypoglycemic activity in Streptozotocin-treated rats, reducing blood glucose levels by 40-70% [PMID:16414865].
Methanolic extracts of rhizomes ameliorated spatial memory deficits in streptozotocin-induced rat models through dual cholinesterase inhibition and attenuation of oxidative stress [PMID:297105 la82].
Evidence DInflammation and Arthritis
The botanical extract IIIM-160 displayed anti-inflammatory, anti-arthritic, and antinociceptive activity in animal models [PMID:30898582].
Evidence DGastric Ulcers
Safety & adverse effects
Acute systemic and intracutaneous toxicity and hemolysis tests were performed, though specific adverse results were not detailed in the provided abstract [PMID:16414865]. The extract IIIM-160 was reported to have an excellent safety-window in acute oral toxicity studies in Swiss albino mice [PMID:30898582].
Dosage & administration
Traditional healers mostly utilize the plant in powder form [PMID:29102914]. No PubMed data available. Consult a healthcare provider.
Evidence summary
The current evidence is primarily based on traditional use (reviews) and preclinical animal models (in vivo rat/mice studies) or in vitro assays. There is a lack of high-level clinical trial data (RCTs) or meta-analyses in the provided set.
PubMed sources
1.PMID: 35567130 (2022) — Bergenia pacumbis (Buch.-Ham. ex D.Don) C.Y.Wu & J.T.Pan: A Comprehensive Review on Traditional Uses, Phytochemistry and Pharmacology. · Plants (Basel, Switzerland)
2.PMID: 29102914 (2018) — Bergenia ciliata: A comprehensive review of its traditional uses, phytochemistry, pharmacology and safety. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
3.PMID: 23256653 (2012) — [Bergenia genus - content matters and biological activity]. · Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti
4.PMID: 35872024 (2023) — Preparation and Characterisation of Liposomes of Bergenia Ciliata Extract and Evaluation of their Hepatoprotective Activity. · Journal of pharmaceutical sciences
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
Methanol extract of rhizomes showed anti-Helicobacter pylori activity, with bergenin identified as the responsible constituent [PMID:30362366].
Evidence DLiver Damage
Liposomes of B. ciliata extract demonstrated hepatoprotective activity against thioacetamide-induced liver damage in rats [PMID:35872024].
(2013)
— Comparative pharmacognostical and phytochemical study on Bergenia ligulata Wall. and Ammania buccifera Linn.
· Ayu
6.PMID: 38091581 (2024) — Development of EST-SSR markers in Bergenia ciliata using de novo transcriptome sequencing. · Genome
7.PMID: 32586304 (2020) — Bergenia pacumbis from Nepal, an astonishing enzymes inhibitor. · BMC complementary medicine and therapies
8.PMID: 30362366 (2020) — Linking traditional anti-ulcer use of rhizomes of Bergenia ciliata (Haw.) to its anti-Helicobacter pylori constituents. · Natural product research
9.PMID: 39577678 (2025) — Antibacterial and antibiofilm activities of extract and bioactive compounds from Bergenia ciliata (Haw.) Sternb. flowers against Streptococcus mutans through cell membrane damage. · Journal of ethnopharmacology
10.PMID: 16414865 (2002) — Bioactivity evaluation of Bergenia ciliata. · Pakistan journal of pharmaceutical sciences
11.PMID: 41547327 (2026) — Dual inhibition of AChE and GSK-3β by flavonoids of Bergenia ciliata: Molecular dynamics insights into anti-Alzheimer's activity. · Computational biology and chemistry
12.PMID: 22557418 (2010) — Effect of Phenolic Compounds from Bergenia ciliata (Haw.) Sternb.leaves on Experimental kidney stones. · Ancient science of life
13.PMID: 37765047 (2023) — Underlying Mechanisms of Bergenia spp. to Treat Hepatocellular Carcinoma Using an Integrated Network Pharmacology and Molecular Docking Approach. · Pharmaceuticals (Basel, Switzerland)
14.PMID: 36509257 (2023) — Comparative appraisal of in vitro biological profile and in vivo wound healing attributes of bergenin and Bergenia ciliata (Haw.) Sternb. · Journal of ethnopharmacology
15.PMID: 40014652 (2025) — Evaluating the Wound Healing Potential of Characterized Bergenia ciliata-Loaded Salvia hispanica Hydrogel in Diabetic Mice. · Microscopy research and technique
16.PMID: 34411656 (2021) — Evaluation of the wound healing activity of ethanolic extract of Bergenia ciliata (Haw.) Sternb. rhizome with excision wound model in Wistar rats. · Journal of ethnopharmacology
18.PMID: 35566808 (2022) — Design and Evaluation of pH-Sensitive Nanoformulation of Bergenin Isolated from Bergenia ciliata. · Polymers
19.PMID: 31694704 (2019) — Isolation of bioactive compounds from Bergenia ciliata (haw.) Sternb rhizome and their antioxidant and anticholinesterase activities. · BMC complementary and alternative medicine
20.PMID: 29710552 (2018) — Bergenia ciliata ameliorates streptozotocin-induced spatial memory deficits through dual cholinesterase inhibition and attenuation of oxidative stress in rats. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
21.PMID: 37654052 (2023) — Application of one-step inner-recycling counter-current chromatography for the preparative separation and purification of chemical constituents from the rhizome of Bergenia ciliate (haw.) Sternb. · Journal of separation science
22.PMID: 32377047 (2020) — Molecular analyses of genetic variability in the populations of Bergenia ciliata in Indian Himalayan Region (IHR). · Physiology and molecular biology of plants : an international journal of functional plant biology
23.PMID: 40542863 (2025) — Assessing the anticancer potential of Bergenia ciliata conjugated silk fibroin nanoparticles through histopathological and biomarkers study. · Journal of molecular histology
24.PMID: 25680842 (2015) — Review on ethnomedicinal, phytochemical and pharmacological evidence of Himalayan anticancer plants. · Journal of ethnopharmacology
25.PMID: 39162271 (2024) — Unveiling the Potential of Bergenia Phenolics: Vitexin's Role in Allosteric Modulation of PBP2a as a Strategy against MRSA Resistance. · Current topics in medicinal chemistry
26.PMID: 37953188 (2024) — Ethno-Dentistry of Medicinal Plants Used in North Waziristan, Pakistan. · International dental journal
27.PMID: 16414873 (2002) — Evaluation of antibacterial activity of Bergenia ciliata. · Pakistan journal of pharmaceutical sciences
28.PMID: 30898582 (2019) — Discovery and preclinical development of IIIM-160, a Bergenia ciliata-based anti-inflammatory and anti-arthritic botanical drug candidate. · Journal of integrative medicine
29.PMID: 30150188 (2018) — Pharmacological and phytochemical analysis of Bergenia ciliata leaf and rhizome extracts. · Pakistan journal of pharmaceutical sciences