Question 1

How does Pegaga (Centella asiatica) work for wound healing?

Accepted Answer

Pegaga contains triterpenoid compounds—asiaticoside, madecassoside, asiatic acid, and madecassic acid—that stimulate collagen synthesis and fibroblast proliferation. These active compounds promote glycosaminoglycan production, supporting connective tissue repair and wound contraction. Additionally, asiaticoside demonstrates antioxidant and anti-inflammatory properties that protect cells from oxidative damage during tissue regeneration. Evidence Level: C and Traditional use support these mechanisms for wound healing and skin conditions.

Question 2

Does Pegaga (Gotu Kola) interact with any medications?

Accepted Answer

Pegaga may interact with hepatotoxic medications, increasing the risk of liver damage when combined with drugs like acetaminophen, statins, or antifungal agents. It may also potentiate sedative effects when taken with CNS depressants, benzodiazepines, or barbiturates, causing excessive drowsiness. Due to potential effects on blood sugar and circulation, individuals taking antidiabetic or anticoagulant medications should consult a healthcare provider before use. Evidence Level: C.

Question 3

What is the recommended dosage for Pegaga (Centella asiatica)?

Accepted Answer

The typical adult dosage for Pegaga extract ranges from 300-680 mg taken three times daily. For traditional Malaysian preparations, fresh leaves can be consumed as food in salads or cooked dishes. Pegaga tea can be consumed 2-3 cups daily. Standardized extracts containing specific amounts of asiaticoside and madecassoside are preferred for therapeutic consistency. Always follow product label instructions and consult a qualified practitioner for individualized dosing. Evidence Level: C.

Question 4

Is Pegaga (Centella asiatica) safe during pregnancy?

Accepted Answer

Pegaga is considered unsafe during pregnancy and should be avoided. Traditional use and available evidence indicate potential risks at therapeutic doses, and the herb is contraindicated for pregnant women, particularly at higher doses. The active triterpenoid compounds may affect hormonal balance and uterine function. Women who are breastfeeding should also exercise caution and consult a healthcare provider before using Pegaga in any form. Evidence Level: C.

Question 5

What are the side effects of taking Pegaga (Gotu Kola)?

Accepted Answer

Common side effects of Pegaga include drowsiness and mild gastrointestinal discomfort. At high doses or with prolonged use, there is a risk of hepatotoxicity (liver damage), making regular liver function monitoring advisable for long-term users. Individuals with pre-existing liver disease should avoid Pegaga entirely. Allergic skin reactions, including contact dermatitis, have been reported with topical applications. Discontinue use if jaundice, abdominal pain, or unusual fatigue occurs. Evidence Level: C.

Question 6

What is Pegaga used for in traditional Malaysian medicine?

Accepted Answer

In traditional Malaysian Jamu preparations, Pegaga is used for cognitive enhancement, wound healing, and skin conditions. It has been historically employed for treating leprosy and supporting memory function. The herb is valued for its ability to promote tissue repair, improve circulation, and support venous insufficiency. Fresh leaves are commonly consumed as a vegetable in salads or cooked dishes as part of daily wellness practices. Evidence Level: C and Traditional.

Pegaga

Sources & Citations

Summary

Background

Traditional uses

Active compounds

Mechanism of action

Clinical evidence

Safety & adverse effects

Evidence summary

PubMed sources

Government sources