PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 20 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Dichloromethane extracts showed selective bacterial inhibition; specifically, one benzopyran compound was active against CA-MRSA and vancomycin-resistant Enterococcus faecalis [PMID:31198050]
Chromanes (peperobtusin A) demonstrated trypanocidal activity with IC50 values as low as 3.1 microM [PMID:19241331]
8-C-rhamnosyl apigenin inhibited edema and myonecrosis induced by sPLA2 by decreasing IL-1β, TNF-α, PGE2, and lipid peroxidation [PMID:28906474]
Peperobtusin A showed antiproliferative activity against PC-3 and HT-29 human cancer cell lines [PMID:35889234]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 35889234 (2022) — Bioactive Phenolic Compounds from Peperomia obtusifolia. · Molecules (Basel, Switzerland)
- 2.PMID: 31198050 (2021) — Antibacterial activity of prenylated benzopyrans from Peperomia obtusifolia (Piperaceae). · Natural product research
- 3.PMID: 21240754 (2011) — Isoswertisin flavones and other constituents from Peperomia obtusifolia. · Natural product research
- 4.PMID: 16660285 (1978) — Responses of succulents to plant water stress. · Plant physiology
- 5.PMID: 29924840 (2018) — Crude leaf extracts of Piperaceae species downmodulate inflammatory responses by human monocytes. · PloS one