This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before using herbs, especially if you are pregnant, nursing, taking medications, or have a medical condition.
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Phyllanthus emblica, commonly known as Indian gooseberry or Amla, is a medicinal plant native to India and Southeast Asia recognized for its potent antioxidant and therapeutic properties [PMID: 35624683, 37727852].
Background
Phyllanthus emblica (also known as Emblica officinalis) is a tree in the Phyllanthaceae family that produces stone fruits rich in vitamin C and polyphenols [PMID: 34480995, 37727852]. It is widely distributed across tropical and subtropical regions, including India, China, Malaysia, and Thailand [PMID: 37954853].
Traditional uses
In indigenous systems such as Ayurveda, Unani, and folklore, it is used to treat common cold, fever, cough, asthma, bronchitis, diabetes, dyspepsia, colic, flatulence, hyperacidity, peptic ulcer, skin diseases, leprosy, anemia, hepatopathy, jaundice, diarrhea, dysentery, cardiac disorders, and premature greying of hair [PMID: 34480995, 20506691, 21317655]. It is also used as a tonic to restore vitality and vigor [PMID: 20506691, 27320046].
Active compounds
The plant contains high levels of vitamin C (ascorbic acid), polyphenols, tannins, flavonoids, phenolic acids, alkaloids, and polysaccharides [PMID: 37727852, 39720042, 39069705, 40829453]. Specific identified compounds include phyllembelic acid, phyllembelin, rutin, curcuminoids, and emblicol [PMID: 20506691].
Mechanism of action
Mechanisms include free radical scavenging, induction of apoptosis, inhibition of cancer cell proliferation, and modulation of oncogenic signaling genes [PMID: 28609132, 34839775]. It also acts via Phase I and II enzyme modifications, anti-inflammatory actions, regulation of the cell cycle, and suppression of methylglyoxal (MG)-derived advanced glycation end products (AGEs) [PMID: 34839775, 36738163].
Clinical evidence
Evidence CCancer Prevention
In multiple rodent models, P. emblica prevented tumor incidence, number, and volume at various organ sites [PMID: 34839775].
Evidence DCognitive Decline (Obesity-induced)
Water extract of Indian gooseberry fruit and gallic acid significantly ameliorated learning and memory deficits and reduced brain MG and AGE levels in HFD-fed rats [PMID: 36738163].
Evidence BPrediabetes
A randomized, controlled study evaluated Nisha-Amalaki capsules (combination of Curcuma longa and Emblica officinalis) for preventing progression to diabetes [PMID: 37857033].
Evidence DObesity and Hyperglycemia
CB-02 capsules (containing P. emblica, Dendrobium catenatum, and Gynostemma pentaphyllum) reduced body weight gain, visceral fat, and improved lipid profiles and insulin sensitivity in obese mice [PMID: 41011571].
Evidence DImmunomodulation
Malaki Rasayana demonstrated significant immunostimulant activity and moderate cytoprotective activity against cyclophosphamide immunosuppression in rats [PMID: 24167334].
Evidence summary
The evidence is primarily based on review articles (Level C) and animal/in vitro studies (Level D), with limited clinical trial data (Level B) regarding specific combined formulations for prediabetes.
PubMed sources
1.PMID: 34480995 (2022) — Traditional uses, bioactive composition, pharmacology, and toxicology of Phyllanthus emblica fruits: A comprehensive review. · Journal of ethnopharmacology
2.PMID: 26180601 (2015) — Anticancer Properties of Phyllanthus emblica (Indian Gooseberry). · Oxidative medicine and cellular longevity
3.PMID: 34839775 (2022) — Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica). · Nutrition and cancer
4.PMID: 23978895 (2013) — Hepatoprotective properties of the Indian gooseberry (Emblica officinalis Gaertn): a review. · Food & function
5.PMID: 37727852 (2023) — Genome of Phyllanthus emblica: the medicinal plant Amla with super antioxidant properties.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
6.PMID: 28609132 (2018) — Antioxidant and anticancer properties of berries. · Critical reviews in food science and nutrition
7.PMID: 35624683 (2022) — Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review. · Antioxidants (Basel, Switzerland)
8.PMID: 20506691 (2010) — Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder. · Journal of basic and clinical physiology and pharmacology
9.PMID: 40829453 (2025) — Recent developments in Phyllanthus emblica (amla) fruit polysaccharides: extraction, purification, nutritional values, structural characterizations and biological activities. · Food chemistry
10.PMID: 35342961 (2022) — Insight about the biochemical composition, postharvest processing, therapeutic potential of Indian gooseberry (amla), and its utilization in development of functional foods-A comprehensive review. · Journal of food biochemistry
11.PMID: 39720042 (2024) — Functional kombucha production from fusions of black tea and Indian gooseberry (Phyllanthus emblica L.). · Heliyon
12.PMID: 36738163 (2023) — Preventive Effect of Indian Gooseberry (Phyllanthus emblica L.) Fruit Extract on Cognitive Decline in High-Fat Diet (HFD)-Fed Rats. · Molecular nutrition & food research
13.PMID: 34229590 (2022) — Indian Indigenous Fruits as Radioprotective Agents: Past, Present and Future. · Anti-cancer agents in medicinal chemistry
14.PMID: 31035513 (2019) — Chyawanprash: A Traditional Indian Bioactive Health Supplement. · Biomolecules
15.PMID: 37954853 (2023) — Phyllanthus emblica: a comprehensive review of its phytochemical composition and pharmacological properties. · Frontiers in pharmacology
16.PMID: 27320046 (2016) — Emblica officinalis (Amla): A review for its phytochemistry, ethnomedicinal uses and medicinal potentials with respect to molecular mechanisms. · Pharmacological research
17.PMID: 38475421 (2024) — Recent Insights into the Morphological, Nutritional and Phytochemical Properties of Indian Gooseberry (Phyllanthus emblica) for the Development of Functional Foods. · Plants (Basel, Switzerland)
18.PMID: 39069705 (2024) — The Phyllanthus emblica Fruits: A Review on Phytochemistry Traditional Uses, Bioactive Composition and Pharmacological Activities. · Current topics in medicinal chemistry
19.PMID: 24167334 (2012) — Immunomodulatory activity of Āmalaki Rasāyana: An experimental evaluation. · Ancient science of life
20.PMID: 34474785 (2021) — Anticoccidial effects of Phyllanthus emblica (Indian gooseberry) extracts: Potential for controlling avian coccidiosis. · Veterinary parasitology, regional studies and reports
21.PMID: 38282828 (2024) — Debittering of Emblica (Phyllanthus emblica L.) fruit powder: Preparation and biological activity. · Food chemistry: X
22.PMID: 37857033 (2023) — A randomized, controlled, comparative, proof-of-concept study to evaluate the efficacy and safety of Nisha-Amalaki capsules in prediabetic patients for preventing progression to diabetes. · Journal of Ayurveda and integrative medicine
23.PMID: 40401115 (2025) — Triphala's characteristics and potential therapeutic uses in modern health. · International journal of physiology, pathophysiology and pharmacology
24.PMID: 35326136 (2022) — Fresh Phyllanthus emblica (Amla) Fruit Supplementation Enhances Milk Fatty Acid Profiles and the Antioxidant Capacities of Milk and Blood in Dairy Cows. · Antioxidants (Basel, Switzerland)
25.PMID: 41011571 (2025) — Anti-Obesity, Lipid-Lowering, and Anti-Hyperglycemic Effects of CB-02 in High-Fat-Diet-Induced Obese Mice. · Molecules (Basel, Switzerland)
26.PMID: 37822817 (2023) — STITCH enabled protein-protein interactions between Phyllanthus emblica and peri-implant microbiome. · Bioinformation
27.PMID: 21317655 (2011) — Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. · European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
28.PMID: 37529983 (2023) — Phyllanthus emblica fruits: a polyphenol-rich fruit with potential benefits for oral management. · Food & function
29.PMID: 37576860 (2023) — Phyllanthus emblica (Amla) methanolic extract regulates multiple checkpoints in 15-lipoxygenase mediated inflammopathies: Computational simulation and in vitro evidence. · Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
30.PMID: 30386531 (2018) — A systematic review on the cardiovascular pharmacology of Emblica officinalis Gaertn. · Journal of cardiovascular and thoracic research