PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Polygonatum sibiricum polysaccharide (PSP) ameliorates skeletal muscle aging and mitochondrial dysfunction in mouse models [PMID:39674120, PMID:38579644]
PSP demonstrates neuroprotective effects, alleviating cuproptosis and improving learning and memory in mouse models [PMID:41687942, PMID:41097234]
PSP reduces diabetic cardiomyopathy by increasing cGMP-PKG signaling and enhances pancreatic beta-cell function via AMPK-SIRT1 [PMID:38553792, PMID:40458823]
Aqueous extracts of P. sibiricum rhizome protect against obesity and liver fat accumulation in high-fat diet-fed mice [PMID:38971026]
PSP effectively decreased serum uric acid levels and alleviated renal tubular epithelial-mesenchymal fibrosis in mice [PMID:39278440]
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 39674120 (2025) — Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 2.PMID: 29757991 (2018) — A Review: The Bioactivities and Pharmacological Applications of Polygonatum sibiricum polysaccharides. · Molecules (Basel, Switzerland)
- 3.PMID: 38484952 (2024) — Research progress on medicinal components and pharmacological activities of polygonatum sibiricum. · Journal of ethnopharmacology
- 4.PMID: 38971026 (2024) — Multiomics reveals the ameliorating effect and underlying mechanism of aqueous extracts of polygonatum sibiricum rhizome on obesity and liver fat accumulation in high-fat diet-fed mice. · Phytomedicine : international journal of phytotherapy and phytopharmacology
- 5.PMID: 38579644