This product is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration.
Zanthoxylum americanum
This herb is NOT recommended during pregnancy due to potential risks to the developing fetus.
This herb is NOT recommended while breastfeeding as effects on infants are unknown.
Consult your healthcare provider before use.
Spiny shrub of North American woodlands; bark and berries used by Indigenous peoples for toothache and circulatory conditions.
Spiny shrub of North American woodlands; bark and berries used by Indigenous peoples for toothache and circulatory conditions. Key active compounds include chelerythrine, berberine, xanthoxylin.
chelerythrine, along with berberine and xanthoxylin, are the primary bioactive compounds in Prickly Ash. These compounds modulates NF-κB and COX-2 inflammatory pathways, disrupts microbial cell membranes and inhibits pathogen growth, acts on pain pathways via anti-inflammatory and neuroactive effects.
Circulatory stimulant
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Analgesic
Limited clinical evidence; primarily supported by traditional use and preliminary studies
Anti-inflammatory
Antimicrobial
Toothache relief in Native American medicine
Based on traditional use; clinical evidence limited
Poor circulation and Raynaud's phenomenon
Based on traditional use; clinical evidence limited
Rheumatism
Based on traditional use; clinical evidence limited
Used by Ojibwe and Menominee tribes
Based on traditional use; clinical evidence limited
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