PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Three isolated compounds from Chinese prickly ash leaves showed antifungal bioactivity by damaging fungal biofilms and potentially recovering sensitivity to Fluconazole in vitro and in vivo [PMID:36211763]
Extracts from Zanthoxylum americanum (fruit and leaf) demonstrated broad-spectrum antifungal activity against 11 strains, including Candida albicans and Aspergillus fumigatus [PMID:15957372]
Hydroxy-γ-sanshool inhibited cell proliferation and induced G1 phase cell cycle arrest in vitro [PMID:35978957]
Polyphenols from Z. bungeanum showed therapeutic potential in animal models for ulcerative colitis, arthritis, asthma, COPD, cardiovascular disease, and neurodegenerative conditions [PMID:38343532]
Evidence summary
PubMed sources
- 1.PMID: 36462661 (2023) — The current situation of Zanthoxylum bungeanum industry and the research and application prospect. A review. · Fitoterapia
- 2.PMID: 34731789 (2022) — Composition, structure and flavor mechanism of numbing substances in Chinese prickly ash in the genus Zanthoxylum: A review. · Food chemistry
- 3.PMID: 36211763 (2022) — Antifungal compounds of Chinese prickly ash against drug-resistant Candida albicans. · Food chemistry: X
- 4.PMID: 38343532 (2024) — Research advances of Zanthoxylum bungeanum Maxim. polyphenols in inflammatory diseases. · Frontiers in immunology
- 5.PMID: 15957372 (2005) — Antifungal constituents of northern prickly ash, Zanthoxylum americanum mill.