PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 29 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Nopal is commonly used as a hypoglycemic agent among persons of Mexican descent [PMID:11926665]; fruit peel extracts showed in vivo hypoglycemic and hypolipidemic properties [PMID:34665433].
Systematic review indicates effectiveness in downregulating cancers by decreasing cell proliferation and tumor weight [PMID:36671035]; extracts suppressed HeLa cervical carcinoma cells [PMID:25379883] and human glioblastoma cells [PMID:20814744].
Methanolic stem extract demonstrated anti-nociceptive and anti-inflammatory effects in mice and rats [PMID:28884086].
Water extract ameliorated loperamide-induced constipation in rats by increasing fecal pellet numbers [PMID:28095842].
Dose-dependently suppressed morphological changes in an asthma murine model, including goblet cell hyperplasia and mucous hypersecretion [PMID:29151835].
Safety & adverse effects
Evidence summary
PubMed sources
- 1.PMID: 11926665 (2002) — Natural products used for diabetes. · Journal of the American Pharmaceutical Association (Washington, D.C. : 1996)
- 2.PMID: 41941578 (2026) — Dermatologic Implications of Prickly Pear Cacti (Opuntia). · Cutis
- 3.PMID: 39109194 (2024) — Opuntia humifusa stems rich in quercetin and isorhamnetin alleviate insulin resistance in high-fat diet-fed rats. · Nutrition research and practice
- 4.PMID: 25379883 (2015) — Anticancer properties of extracts from Opuntia humifusa against human cervical carcinoma cells. · Journal of medicinal food
- 5.PMID: 31353577 (2019) — Biological activities of water-soluble polysaccharides from Opuntia humifusa stem in high-fat-diet-fed mice.