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This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Punarnava (Boerhavia diffusa) is a medicinal herb used in Ayurvedic tradition for its anti-inflammatory, hepatoprotective, and nephroprotective properties [PMID:40334820, PMID:41355611].
Background
Boerhavia diffusa L. is a perennial herb from the Nyctaginaceae family native to tropical and subtropical regions of Asia and surrounding continents [PMID:41355611].
Traditional uses
It is traditionally used in India, China, and Japan to treat liver ailments, kidney disorders, cardiovascular diseases, urinary tract infections, arthritis, asthma, and anemia [PMID:40334820, PMID:41355611, PMID:42238151]. It is also used as a rejuvenator ('Rasayan') for antiaging and antioxidant purposes [PMID:38033469, PMID:24949473].
Active compounds
Phytochemicals include alkaloids, flavonoids (such as rutin and eupalitin 3-O-β-D-galactopyranoside), glycosides (including punarnavoside), phenolics, saponins, rotenoids, xanthones, purine nucleosides, lignans, and steroids [PMID:40334820, PMID:41355611, PMID:36648730, PMID:39771606, PMID:24949473, PMID:37556882].
Mechanism of action
Potential mechanisms include inhibition of the Angiotensin-converting enzyme (ACE) for antihypertensive effects [PMID:39771606], blocking cannabinoid receptors for anti-obesity action [PMID:35567159], and inhibiting the quorum sensing (QS) network circuit of Pseudomonas aeruginosa [PMID:37808386].
Clinical evidence
Evidence BIron Deficiency Anemia in Pregnancy
Punarnava Mandura was evaluated for efficacy in managing Garbhini Pandu (anemia in pregnancy) [PMID:27833367]
Evidence BMicroalbuminuria in Diabetes Mellitus
Gokshura-Punarnava Basti was evaluated for the management of microalbuminuria [PMID:23723672]
Evidence DAlopecia Totalis
A case report indicated effective management of Alopecia totalis using a combination of Ayurvedic treatments including Punarnava Mandoor [PMID:38043433]
Evidence DNephrotoxicity (Animal Models)
Root extracts showed protective effects against gentamicin-induced and methotrexate-induced renal injury in rats [PMID:26166999, PMID:42046059]
Evidence DHypertension (Animal Model)
Eupalitin 3-O-β-D-galactopyranoside isolated from leaves showed potential antihypertensive effects in rats [PMID:39771606]
Safety & adverse effects
Case reports have linked Punarnava mandur to drug-induced liver injury [PMID:29152040]. Additionally, a case of suspected cutaneous allergic reactions (skin rashes) was reported following the use of Punarnava Mandura [PMID:38716496].
Pregnancy & lactation
Punarnava Mandura has been used in the clinical management of anemia during pregnancy [PMID:27833367].
Drug interactions
Studies have investigated the effects of Boerhavia diffusa extracts on drug metabolizing enzymes CYP1A2, CYP2D6, and CYP3A4 to predict potential herb-drug interactions [PMID:28942133].
Evidence summary
Evidence consists primarily of traditional use reviews, animal models (nephroprotection, antihypertension), and isolated case reports. Clinical evidence in humans is limited to small-scale trials and case reports.
PubMed sources
1.PMID: 29152040 (2017) — Ayurvedic drug induced liver injury. · World journal of hepatology
2.PMID: 36648730 (2023) — Mitigating the nephrotoxic impact of hexavalent chromium in Ctenopharyngodon idellus (grass carp) with Boerhavia diffusa (punarnava) leaf extract. · Environmental science and pollution research international
3.PMID: 37808386 (2023) — Anti-quorum sensing activity of Boerhavia diffusa against Pseudomonas aeruginosa PAO1. · Bioinformation
4.PMID: 38716496 (2025) — Suspected Cutaneous Allergic Reactions with Ayurveda Medicine Punaranava Mandura: A Case Report. · Current drug safety
5.PMID: 40334820 (2025) — A comprehensive review of the phytochemistry, pharmacology, pharmacokinetics, and green nanotechnological significance of Boerhavia diffusa Linn.
Government sources
No direct government monograph is available for this herb. The content below is AI-generated and has not been verified against an authoritative government source. Use the search links to check official sources before relying on this information.
8.PMID: 38033469 (2023) — Ethnomedicinal values of Boerhaavia diffusa L. as a panacea against multiple human ailments: a state of art review. · Frontiers in chemistry
9.PMID: 42238151 (2026) — Punarnavayolepa Choornam in Iron Deficiency Anemia Management: Pharmaceutical Insights and Biological Activity. · Cureus
10.PMID: 39771606 (2024) — Molecular Docking and Antihypertensive Activity of Eupalitin 3-O-β-D-galactopyranoside Isolated from Boerhavia diffusa Linn. · Pharmaceutics
11.PMID: 26166999 (2015) — Evaluation of the effect of Boerhavia diffusa on gentamicin-induced nephrotoxicity in rats. · Journal of Ayurveda and integrative medicine
12.PMID: 24949473 (2014) — Phytochemical, therapeutic, and ethnopharmacological overview for a traditionally important herb: Boerhavia diffusa Linn. · BioMed research international
13.PMID: 28942133 (2018) — Bush mint (Hyptis suaveolens) and spreading hogweed (Boerhavia diffusa) medicinal plant extracts differentially affect activities of CYP1A2, CYP2D6 and CYP3A4 enzymes. · Journal of ethnopharmacology
14.PMID: 35567159 (2022) — Anti-Obesity Action of Boerhavia diffusa in Rats against High-Fat Diet-Induced Obesity by Blocking the Cannabinoid Receptors. · Plants (Basel, Switzerland)
15.PMID: 23723672 (2012) — Clinical efficacy of Gokshura-Punarnava Basti in the management of microalbuminuria in diabetes mellitus. · Ayu
16.PMID: 42046059 (2026) — Protective role of Boerhavia diffusa root extract in methotrexate-induced renal injury: evidence from oxidative stress, molecular, and immunohistochemical markers. · BMC complementary medicine and therapies
17.PMID: 37556882 (2023) — Small size silver nanoparticles loaded with glycoside rich portion of Boerhavia Diffusa Linn. promotes wound healing: in-silico and in-vivo studies. · Colloids and surfaces. B, Biointerfaces
18.PMID: 27833367 (2015) — Clinical efficacy of Punarnava Mandura and Dhatri Lauha in the management of Garbhini Pandu (anemia in pregnancy). · Ayu