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PubMed · Scorpion (Buthus martensii Karsch) in Chinese medicine: a review of traditional uses, chemical constituents, pharmacology, and toxicology. (2025)
PubMed · Anti-epileptic/pro-epileptic effects of sodium channel modulators from Buthus martensii Karsch. (2022)
Reviewed by: HerbAlly Editorial Team, Medical herbalists and healthcare professionals
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 28 PubMed articles · model: gemma4:31b
Summary
Quan Xie (Buthus martensii Karsch) is a scorpion species whose venom contains bioactive peptides with potential analgesic, antitumor, and anti-epileptic properties [PMID:30858089, PMID:33178316].
Background
Buthus martensii Karsch (BmK) is a scorpion species from China [PMID:24577583, PMID:30858089]. Its venom is a complex mixture of proteins, including neurotoxins and other bioactive peptides [PMID:19931296, PMID:30858089].
Traditional uses
In China, Buthus martensii Karsch-analgesic-antitumor peptide (BmK AGAP) has been used to treat cancer, epilepsy, tetanus, tuberculosis, apoplexy, spasm, migraine headaches, and rheumatic pain [PMID:33178316].
Active compounds
Active components include the analgesic-antitumor peptide (BmK AGAP), a long-chain toxin of 66 amino acids [PMID:33178316], and Martentoxin (MarTX) [PMID:38112732]. Other venom components include Na+, K+, Ca2+, Cl- and TRP channel toxins, enzymes, and protease inhibitors [PMID:31834817].
Injection of Martentoxin (MarTX) into the hippocampal region of mice significantly alleviated convulsive seizures; however, intravenous efficacy required TAT-modification to cross the blood-brain barrier [PMID:38112732]
Evidence CPain and Cancer
The BmK AGAP peptide is reported to have analgesic and antitumor properties [PMID:33178316]
Safety & adverse effects
Scorpion venom can cause severe medical complications, including neurotoxicity, cardiovascular collapse, respiratory dysfunction, and death if injected into the human body [PMID:29999659, PMID:34055554]. Specific complications include myocarditis [PMID:37018229], nephropathy [PMID:25984198], and Takotsubo cardiomyopathy [PMID:38205067].
Pregnancy & lactation
Data on the effects of scorpion stings in pregnant women are very limited [PMID:28613678, PMID:27255088]. No information is available on the clinical use of Centruroides immune f(ab)2 during breastfeeding [PMID:29999659].
Evidence summary
Evidence for the therapeutic use of Buthus martensii Karsch is primarily based on laboratory research (animal models) and literature reviews; there is a lack of high-level human clinical trial data for these specific medicinal applications.
PubMed sources
1.PMID: 31834817 (2020) — Scorpion venomics: a 2019 overview. · Expert review of proteomics
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— Scorpion envenomation-associated myocarditis: A systematic review.
· PLoS neglected tropical diseases
7.PMID: 25984198 (2011) — Scorpion sting nephropathy. · NDT plus
8.PMID: 19931296 (2010) — Mining on scorpion venom biodiversity. · Toxicon : official journal of the International Society on Toxinology
9.PMID: 33178316 (2020) — The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer. · Evidence-based complementary and alternative medicine : eCAM
10.PMID: 31228480 (2019) — Scorpion envenomation and inflammation: Beyond neurotoxic effects. · Toxicon : official journal of the International Society on Toxinology
12.PMID: 27255088 (2016) — Scorpion Envenomation in Pregnancy. · Southern medical journal
13.PMID: 36567038 (2023) — Ethnomedicines for the treatment of scorpion stings: A perspective study. · Journal of ethnopharmacology
14.PMID: 34055554 (2021) — Neurological and Systemic Manifestations of Severe Scorpion Envenomation. · Cureus
15.PMID: 38205067 (2023) — Takotsubo cardiomyopathy following scorpion envenomation: a literature review. · American journal of cardiovascular disease
16.PMID: 24577583 (2014) — Overview of scorpion species from China and their toxins. · Toxins
17.PMID: 30858089 (2019) — Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch. · Peptides
18.PMID: 25701676 (2015) — Evolution of alternative methodologies of scorpion antivenoms production. · Toxicon : official journal of the International Society on Toxinology
19.PMID: 11273325 (1998) — Scorpion sting. · The Journal of the Association of Physicians of India
20.PMID: 22715546 (2012) — Scorpion sting: update. · The Journal of the Association of Physicians of India
21.PMID: 28509171 (2016) — Nephrotic syndrome after scorpion sting. · CEN case reports
22.PMID: 36641229 (2023) — Bioactive peptides from scorpion venoms: therapeutic scaffolds and pharmacological tools. · Chinese journal of natural medicines
25.PMID: 16387337 (2006) — Genetic mechanisms of scorpion venom peptide diversification. · Toxicon : official journal of the International Society on Toxinology
26.PMID: 7801339 (1994) — Scorpion envenoming and the role of insulin. · Toxicon : official journal of the International Society on Toxinology
27.PMID: 27397476 (2016) — Scorpion Toxin Polyptides as Therapeutic Agents: An Overview. · Protein and peptide letters