PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Reseda luteola L., commonly known as weld, is a plant traditionally used as a source of yellow dye due to its high flavone content [PMID:19960424, PMID:21999916].
Background
Reseda luteola L. (weld) is a tinctorial plant used since ancient times for textile dyeing [PMID:19960424, PMID:21999916].
Traditional uses
It has been used as a dye due to its high luteolin content since ancient times [PMID:19960424].
Active compounds
The plant contains flavones, primarily luteolin, luteolin-7-O-glucoside, luteolin-7,3'-O-diglucoside, apigenin, apigenin 7-O-glucoside, luteolin 3',7-O-diglucoside, and luteolin 4'-O-glucoside [PMID:19890841, PMID:19960424, PMID:21999916]. It also contains polyphenols [PMID:40871598] and lignin [PMID:38642685].
Mechanism of action
Luteolin-rich extracts have demonstrated antiproliferative and pro-apoptotic activities in PHA-stimulated peripheral blood mononuclear cells [PMID:19960424].
Clinical evidence
Evidence BUVB-induced inflammation
Topical application of a solubilized luteolin-rich Reseda extract (2.5% w/w) dose-dependently reduced UVB-induced erythema when applied 30 minutes before irradiation [PMID:19656689].
Safety & adverse effects
Lignin extracted from Reseda luteola L. waste was validated as eco-friendly through acute toxicity tests with Artemia salina [PMID:40555960].
Evidence summary
Evidence is limited to laboratory-based pharmacological studies (antiproliferative effects), chemical characterization of dyes, and one randomized double-blind placebo-controlled trial regarding topical anti-inflammatory effects.
PubMed sources
- 1.PMID: 38642685 (2024) — High extraction and excellent anti-UV and anti-oxidant proprieties of lignin from Reseda Luteola L. waste by organosolv process. · International journal of biological macromolecules
- 2.PMID: 40871598 (2025) — Controlled Silver Nanoparticle Formation in Hair Fibers Dyed with Reseda luteola L.: A Study on Additive-Dependent Penetration and Aggregation. · Molecules (Basel, Switzerland)
- 3.PMID: 21999916 (2011) — Fast chromatographic separation for the quantitation of the main flavone dyes in Reseda luteola (weld). · Journal of chromatography. A
- 4.PMID: 19960424 (2010) — Reseda luteola L. extract displays antiproliferative and pro-apoptotic activities that are related to its major flavonoids. · Phytotherapy research : PTR
- 5.PMID: 19890841 (2009) — Influence of soil fertility on dye flavonoids production in weld (Reseda luteola L.) accessions from Portugal.