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PubMed · Unraveling the Potential Role of <i>Tecomella undulata</i> in Experimental NASH. (2023)
PubMed · Ethnomedicinal, phytochemical, pharmacological, and conservation studies of an endangered plant: the desert teak (<i>Tecomella undulata</i> (Sm.) Seem.). (2025)
Reviewed by: HerbAlly Editorial Team, Medical herbalists and healthcare professionals
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Tecomella undulata, also known as Rohitaka or desert teak, is an endangered medicinal plant native to South Asia used traditionally for liver, skin, and metabolic disorders [PMID:41333022, PMID:36834657].
Background
Tecomella undulata (Sm.) Seem. is an endangered tree species native to India, Afghanistan, Iran, Oman, and Pakistan [PMID:41333022].
Traditional uses
In India, the stem bark is used to treat leucorrhea, pain, sexual disorders, digestive disorders, eczema, skin infections, syphilis, painful swellings, cancer, urinary discharges, enlargement of spleen, leukoderma, tumors, liver disorders, gonorrhea, gout, and to promote wound healing [PMID:41333022, PMID:21843623]. In Pakistan, flowers and stem bark are used for hepatitis, jaundice, sexual disorders, anorexia, constipation, and menstrual disorders [PMID:41333022].
Active compounds
Bioactive metabolites include phenolic metabolites, flavonoids, steroids, alkaloids, terpenoids, fatty acids, quinones [PMID:41333022], betulinic acid [PMID:22789967, PMID:27058523], and the iridoid glucoside undulatin [PMID:17345339]. Specific quinones isolated from heartwood include tectonaquinone B, 2-methylquinizarin, tecomaquinone I, lapachol, 2-isopropenylnaphtho[2,3-b]-furan-4,9-quinone, dehydro-α-lapachone, α-lapachone, and β-lapachone [PMID:36411529].
Mechanism of action
In experimental NASH, it alleviates endoplasmic reticulum stress and oxidative stress while enhancing antioxidant status [PMID:36834657]. It may exhibit anticancer activity by inhibiting CDK7 via interaction with Met94 [PMID:36411529] and modulate SIRT1 and its downstream adipogenesis mediators (PPARγ, C/EBPα, E2F1, leptin, adiponectin, and LPL) for anti-obesity effects [PMID:23628454].
Clinical evidence
Evidence DNonalcoholic Steatohepatitis (NASH)
In WDSW-fed mice, oral administration lowered body weight, insulin resistance, ALT, AST, triglycerides, and total cholesterol, and resolved NASH by improving steatosis, lobular inflammation, and hepatocyte ballooning [PMID:36834657]
Evidence DHepatotoxicity (Thioacetamide-induced)
Ethanolic extract of stem bark (1000 mg/kg/day) significantly reduced serum AST, ALT, gamma glutamyl transpeptidase, and alkaline phosphatase in rats [PMID:19059328]
Evidence DHepatotoxicity (CCl4-induced)
Stem bark methanolic extract and betulinic acid demonstrated hepatoprotective potential in rats [PMID:22789967]
Evidence DType 2 Diabetes
Ethanolic extract of leaves showed significant blood glucose lowering effects in oral glucose tolerance tests and influenced cholesterol and glycosylated hemoglobin in streptozotocin-nicotinamide induced diabetic rats [PMID:22769229]
Evidence DObesity
Ethyl acetate extract of bark showed anti-obesity efficiency in 3T3-L1 fibroblasts and HFD obese mice via modulation of SIRT1 [PMID:23628454]
Evidence summary
The current evidence is primarily based on in vitro studies and animal models (Level D), demonstrating potential hepatoprotective, anti-diabetic, anti-obesity, and anticancer activities. No human clinical trials were provided in the source abstracts.
PubMed sources
1.PMID: 36834657 (2023) — Unraveling the Potential Role of Tecomella undulata in Experimental NASH. · International journal of molecular sciences
2.PMID: 41333022 (2025) — Ethnomedicinal, phytochemical, pharmacological, and conservation studies of an endangered plant: the desert teak (Tecomella undulata (Sm.) Seem.). · Frontiers in pharmacology
3.PMID: 35531249 (2022) — Biochemical characterization, cytotoxic, antimutagenic, anticancer and molecular docking studies on Tecomella undulata. · Saudi journal of biological sciences
4.PMID: 36411529 (2022) — Study of potent CDK7 inhibitor secondary metabolites from Tecomella undulata. · Natural product research
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Methanol extract showed 68.1% cytotoxicity in carcinoma cell lines and effectiveness against liver HepG-2 cells [PMID:35531249]; chloroform extract of bark induced apoptosis in K562 leukemia cells [PMID:21843623]
Evidence DPain
Methanolic extract of the whole plant demonstrated analgesic potential in mice [PMID:7934089]
— Preclinical Hepatoprotective Effect of Herbalism Against Ethanol Induced Hepatotoxicity: A Review.
· Current drug metabolism
6.PMID: 39584039 (2024) — Quorum quenching activity of endophytic Bacillus sp. EBS9 from Tecomella undulata and its biocontrol applications. · Current research in microbial sciences
7.PMID: 36087183 (2023) — Ruminal fermentation and methane production in vitro, milk production, nutrient utilization, blood profile, and immune responses of lactating goats fed polyphenolic and saponin-rich plant extracts. · Environmental science and pollution research international
8.PMID: 23628454 (2013) — Scientific evidence for traditional claim of anti-obesity activity of Tecomella undulata bark. · Journal of ethnopharmacology
9.PMID: 21843623 (2011) — Antiproliferative activity and standardization of Tecomella undulata bark extract on K562 cells. · Journal of ethnopharmacology
10.PMID: 22769229 (2012) — In vivo anti-hyperglycemic and antioxidant potentials of ethanolic extract from Tecomella undulata. · Diabetology & metabolic syndrome
11.PMID: 19059328 (2009) — Evaluation of hepatoprotective activity of aerial parts of Tephrosia purpurea L. and stem bark of Tecomella undulata. · Journal of ethnopharmacology
12.PMID: 22789967 (2012) — Hepatoprotective potential of Tecomella undulata stem bark is partially due to the presence of betulinic acid. · Journal of ethnopharmacology
13.PMID: 27058523 (2016) — Optimization of Betulinic Acid Extraction from Tecomella undulata Bark Using a Box-Behnken Design and Its Densitometric Validation. · Molecules (Basel, Switzerland)
14.PMID: 22556621 (1993) — Pharmacognostical, phytochemical and antimicrobial studies on stem bark of tecomella undulata seem. · Ancient science of life
15.PMID: 17345339 (1986) — Structure of Undulatin: A New Iridoid Glucoside from Tecomella undulata. · Planta medica
16.PMID: 27393436 (2016) — Designing of a phytosome dosage form with Tecomella undulata as a novel drug delivery for better utilization. · Pakistan journal of pharmaceutical sciences
17.PMID: 7934089 (1994) — Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulata for analgesic and anti-inflammatory activities. · Journal of ethnopharmacology
18.PMID: 27094273 (2016) — Simultaneously removal of inorganic arsenic species from stored rainwater in arsenic endemic area by leaves of Tecomella undulata: a multivariate study. · Environmental science and pollution research international
19.PMID: 26921585 (2016) — Biosorptive removal of inorganic arsenic species and fluoride from aqueous medium by the stem of Tecomella undulate. · Chemosphere