PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 16 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Extracts demonstrated antioxidant and anti-inflammatory effects and acted as oral anti-diabetic agents [PMID:23159471].
Urtica pilulifera helped control blood glucose, lipids, and oxidative stress [PMID:32801429].
Lectin isolated from seeds showed significant hypoglycemic effects at a dose of 100 mg/kg [PMID:12648821].
Seed extract promoted folliculogenesis, reduced apoptosis, and decreased malondialdehyde concentration [PMID:38628780].
Leaf extract mitigated liver toxicity by modulating antioxidants and inflammatory markers [PMID:38469182].
Hexanic extract and specifically fraction 4 (containing phytol) showed potent cytotoxicity and antiproliferative effects [PMID:36789820].
Evidence summary
PubMed sources
- 1.PMID: 23159471 (2013) — Antioxidant and anti-inflammatory effects of Urtica pilulifera extracts in type 2 diabetic rats. · Journal of ethnopharmacology
- 2.PMID: 41220369 (2025) — Comprehensive study of Algerian nettles: Phenolic content and multifunctional activities of Urtica pilulifera and Urtica urens. · Animal models and experimental medicine
- 3.PMID: 32801429 (2020) — Urtica Pilulifera in Treating Pre-diabetic Rat Model to Control the Blood Glucose, Lipids and Oxidative Stress. · Medical archives (Sarajevo, Bosnia and Herzegovina)
- 4.PMID: 12648821 (2003) — Hypoglycemic activity of Urtica pilulifera in streptozotocin-diabetic rats. · Journal of ethnopharmacology
- 5.PMID: 30257584 (2018)