PubMed-compiled information sheet
This sheet was compiled from PubMed (NIH) abstracts using AI assistance. Every factual claim is cited to a real PubMed article (see the source list). It has not yet been human-reviewed — confirm with a healthcare provider before use.
Compiled from 30 PubMed articles · model: gemma4:31b
Summary
Background
Traditional uses
Active compounds
Mechanism of action
Clinical evidence
Flavonoids reduced IL-6, IL-1β, and TNF-α expression, diminished neutrophil extracellular traps (NETs) release, and reduced macrophage pyroptosis in mice [PMID:40617042]
Fermented and raw juice ameliorated hyperglycemia, dyslipidemia, and abnormal hepatic function, and restored insulin expression levels in rats [PMID:40458826]; fruit vinegar improved NAFLD by regulating intestinal microbiota in high-fat diet mice [PMID:40873448]
Polyphenols and nanogel-encapsulated polyphenols alleviated DSS-induced colitis, preserved intestinal barrier integrity, and inhibited PI3K/Akt/mTOR and NF-κB signaling pathways [PMID:40253185, PMID:41539761]
Kaji-ichigoside F1 showed antidepressant effects in mouse models [PMID:40308754]; fermented juice mitigated CUMS-induced depressive-like behaviors and hippocampal damage by remodeling gut microbiota [PMID:41474946]
Euscaphic acid inhibited the viability, proliferation, migration, and invasion of HCT116 and CT26 cells and inhibited graft tumor growth in vivo [PMID:41111080]
Evidence summary
PubMed sources
- 1.PMID: 33002536 (2020) — Extraction optimization, physicochemical properties and antioxidant and hypoglycemic activities of polysaccharides from roxburgh rose (Rosa roxburghii Tratt.) leaves. · International journal of biological macromolecules
- 2.PMID: 41828819 (2026) — Comparative Metabolomics and Transcriptomics Analysis of Rosa roxburghii Tratt and Rosa kweichonensis var. sterilis. · Molecules (Basel, Switzerland)
- 3.PMID: 40322293 (2025) — Potential of Fruits to Improve Dyslipidemias: A Pilot Review. · Vascular health and risk management
- 4.PMID: 40617042 (2025) — The flavonoids of Rosa roxburghii Tratt alleviate endotoxemia progression by inhibiting the proinflammatory effects of neutrophil and macrophage via ROS/NLRP3 signaling pathway. · International immunopharmacology
- 5.PMID: 37299173